Redesigning metabolism based on orthogonality principles
Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization t...
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Autores principales: | Aditya Vikram Pandit, Shyam Srinivasan, Radhakrishnan Mahadevan |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/5fcc9a50e6a74fc7a3de77700c2ed0d3 |
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