Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study

The purpose of this study was to assess the safety and efficacy of chitosan–platelet-rich plasma (PRP) hybrid implants used as an adjunct to surgical rotator cuff repair in a pivotal Good Laboratory Practice (GLP)-compliant study. The infraspinatus tendon was transected in 48 skeletally mature ewes...

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Autores principales:	Anik Chevrier, Mark B. Hurtig, Marc Lavertu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chitosan platelet-rich plasma rotator cuff repair sheep model Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5fcd6215c5f14840acf7e05d57fb30d8
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spelling	oai:doaj.org-article:5fcd6215c5f14840acf7e05d57fb30d82021-11-25T18:42:21ZChitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study10.3390/pharmaceutics131119551999-4923https://doaj.org/article/5fcd6215c5f14840acf7e05d57fb30d82021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1955https://doaj.org/toc/1999-4923The purpose of this study was to assess the safety and efficacy of chitosan–platelet-rich plasma (PRP) hybrid implants used as an adjunct to surgical rotator cuff repair in a pivotal Good Laboratory Practice (GLP)-compliant study. The infraspinatus tendon was transected in 48 skeletally mature ewes and repaired with a transosseous-equivalent (TOE) technique. In the two treatment groups, a chitosan–PRP solution was injected at the footprint between the tendon and the bone and on top of the repaired site (2 mL or 3 mL doses, <i>n</i> = 12 per group). To further assess chitosan safety, a chitosan–water solution was injected at the same sites (3 mL, <i>n</i> = 12). Outcome measures included Magnetic Resonance Imaging (MRI) assessment and clinical pathology at 3 months and 6 months and histopathology at 6 months. The tendon gap was decreased at 3 months on MRI images and certain histopathological features were improved at 6 months by chitosan–PRP treatment compared to controls. The group treated with chitosan–water was not different from controls. Chitosan–PRP treatment induced no negative effects in the sheep, which suggests high safety. This study provides further evidence on the safety and efficacy of chitosan–PRP for rotator cuff repair augmentation, which could eventually be used in a clinical setting.Anik ChevrierMark B. HurtigMarc LavertuMDPI AGarticlechitosanplatelet-rich plasmarotator cuff repairsheep modelPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1955, p 1955 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan platelet-rich plasma rotator cuff repair sheep model Pharmacy and materia medica RS1-441
spellingShingle	chitosan platelet-rich plasma rotator cuff repair sheep model Pharmacy and materia medica RS1-441 Anik Chevrier Mark B. Hurtig Marc Lavertu Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
description	The purpose of this study was to assess the safety and efficacy of chitosan–platelet-rich plasma (PRP) hybrid implants used as an adjunct to surgical rotator cuff repair in a pivotal Good Laboratory Practice (GLP)-compliant study. The infraspinatus tendon was transected in 48 skeletally mature ewes and repaired with a transosseous-equivalent (TOE) technique. In the two treatment groups, a chitosan–PRP solution was injected at the footprint between the tendon and the bone and on top of the repaired site (2 mL or 3 mL doses, <i>n</i> = 12 per group). To further assess chitosan safety, a chitosan–water solution was injected at the same sites (3 mL, <i>n</i> = 12). Outcome measures included Magnetic Resonance Imaging (MRI) assessment and clinical pathology at 3 months and 6 months and histopathology at 6 months. The tendon gap was decreased at 3 months on MRI images and certain histopathological features were improved at 6 months by chitosan–PRP treatment compared to controls. The group treated with chitosan–water was not different from controls. Chitosan–PRP treatment induced no negative effects in the sheep, which suggests high safety. This study provides further evidence on the safety and efficacy of chitosan–PRP for rotator cuff repair augmentation, which could eventually be used in a clinical setting.
format	article
author	Anik Chevrier Mark B. Hurtig Marc Lavertu
author_facet	Anik Chevrier Mark B. Hurtig Marc Lavertu
author_sort	Anik Chevrier
title	Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
title_short	Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
title_full	Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
title_fullStr	Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
title_full_unstemmed	Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study
title_sort	chitosan–platelet-rich plasma implants improve rotator cuff repair in a large animal model: pivotal study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5fcd6215c5f14840acf7e05d57fb30d8
work_keys_str_mv	AT anikchevrier chitosanplateletrichplasmaimplantsimproverotatorcuffrepairinalargeanimalmodelpivotalstudy AT markbhurtig chitosanplateletrichplasmaimplantsimproverotatorcuffrepairinalargeanimalmodelpivotalstudy AT marclavertu chitosanplateletrichplasmaimplantsimproverotatorcuffrepairinalargeanimalmodelpivotalstudy
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Chitosan–Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study

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