The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.

Guardado en:

Detalles Bibliográficos
Autores principales:	Thomas M. Ashton, Emmanouil Fokas, Leoni A. Kunz-Schughart, Lisa K. Folkes, Selvakumar Anbalagan, Melanie Huether, Catherine J. Kelly, Giacomo Pirovano, Francesca M. Buffa, Ester M. Hammond, Michael Stratford, Ruth J. Muschel, Geoff S. Higgins, William Gillies McKenna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5fcde319119841a9a1a9daedc3b99552
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5fcde319119841a9a1a9daedc3b99552
record_format	dspace
spelling	oai:doaj.org-article:5fcde319119841a9a1a9daedc3b995522021-12-02T17:31:19ZThe anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia10.1038/ncomms123082041-1723https://doaj.org/article/5fcde319119841a9a1a9daedc3b995522016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12308https://doaj.org/toc/2041-1723Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.Thomas M. AshtonEmmanouil FokasLeoni A. Kunz-SchughartLisa K. FolkesSelvakumar AnbalaganMelanie HuetherCatherine J. KellyGiacomo PirovanoFrancesca M. BuffaEster M. HammondMichael StratfordRuth J. MuschelGeoff S. HigginsWilliam Gillies McKennaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
description	Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.
format	article
author	Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna
author_facet	Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna
author_sort	Thomas M. Ashton
title	The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
title_short	The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
title_full	The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
title_fullStr	The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
title_full_unstemmed	The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
title_sort	anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5fcde319119841a9a1a9daedc3b99552
work_keys_str_mv	AT thomasmashton theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT emmanouilfokas theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT leoniakunzschughart theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT lisakfolkes theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT selvakumaranbalagan theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT melaniehuether theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT catherinejkelly theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT giacomopirovano theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT francescambuffa theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT estermhammond theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT michaelstratford theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT ruthjmuschel theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT geoffshiggins theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT williamgilliesmckenna theantimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT thomasmashton antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT emmanouilfokas antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT leoniakunzschughart antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT lisakfolkes antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT selvakumaranbalagan antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT melaniehuether antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT catherinejkelly antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT giacomopirovano antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT francescambuffa antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT estermhammond antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT michaelstratford antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT ruthjmuschel antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT geoffshiggins antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia AT williamgilliesmckenna antimalarialatovaquoneincreasesradiosensitivitybyalleviatingtumourhypoxia
_version_	1718380615026343936

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Ejemplares similares