Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

Trisomy 21 (T21) is a major cause of Down syndrome but little is known about its impact on the cellular proteome. Here, the authors define the proteome of T21 fibroblasts and its turnover and also map proteomic differences in monozygotic T21-discordant twins, revealing extensive, organelle-specific...

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Autores principales:	Yansheng Liu, Christelle Borel, Li Li, Torsten Müller, Evan G. Williams, Pierre-Luc Germain, Marija Buljan, Tatjana Sajic, Paul J. Boersema, Wenguang Shao, Marco Faini, Giuseppe Testa, Andreas Beyer, Stylianos E. Antonarakis, Ruedi Aebersold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c7
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spelling	oai:doaj.org-article:5fd1464d14644e54b82f2a253ca5d0c72021-12-02T14:41:08ZSystematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells10.1038/s41467-017-01422-62041-1723https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c72017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01422-6https://doaj.org/toc/2041-1723Trisomy 21 (T21) is a major cause of Down syndrome but little is known about its impact on the cellular proteome. Here, the authors define the proteome of T21 fibroblasts and its turnover and also map proteomic differences in monozygotic T21-discordant twins, revealing extensive, organelle-specific changes caused by T21.Yansheng LiuChristelle BorelLi LiTorsten MüllerEvan G. WilliamsPierre-Luc GermainMarija BuljanTatjana SajicPaul J. BoersemaWenguang ShaoMarco FainiGiuseppe TestaAndreas BeyerStylianos E. AntonarakisRuedi AebersoldNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yansheng Liu Christelle Borel Li Li Torsten Müller Evan G. Williams Pierre-Luc Germain Marija Buljan Tatjana Sajic Paul J. Boersema Wenguang Shao Marco Faini Giuseppe Testa Andreas Beyer Stylianos E. Antonarakis Ruedi Aebersold Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
description	Trisomy 21 (T21) is a major cause of Down syndrome but little is known about its impact on the cellular proteome. Here, the authors define the proteome of T21 fibroblasts and its turnover and also map proteomic differences in monozygotic T21-discordant twins, revealing extensive, organelle-specific changes caused by T21.
format	article
author	Yansheng Liu Christelle Borel Li Li Torsten Müller Evan G. Williams Pierre-Luc Germain Marija Buljan Tatjana Sajic Paul J. Boersema Wenguang Shao Marco Faini Giuseppe Testa Andreas Beyer Stylianos E. Antonarakis Ruedi Aebersold
author_facet	Yansheng Liu Christelle Borel Li Li Torsten Müller Evan G. Williams Pierre-Luc Germain Marija Buljan Tatjana Sajic Paul J. Boersema Wenguang Shao Marco Faini Giuseppe Testa Andreas Beyer Stylianos E. Antonarakis Ruedi Aebersold
author_sort	Yansheng Liu
title	Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
title_short	Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
title_full	Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
title_fullStr	Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
title_full_unstemmed	Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
title_sort	systematic proteome and proteostasis profiling in human trisomy 21 fibroblast cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c7
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Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

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