Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis

Mami Ishihara, Akira Meguro, Mizuho Ishido, Masaki Takeuchi, Etsuko Shibuya, Nobuhisa Mizuki Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, JapanCorrespondence: Mami Ishihara; Akira Meguro Tel +81-45-787-2683Fax +81-...

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Autores principales:	Ishihara M, Meguro A, Ishido M, Takeuchi M, Shibuya E, Mizuki N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sarcoid uveitis soluble interleukin-2 receptors (sil-2r) angiotensin-converting enzyme (ace) primary intraocular lymphoma (piol) Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5fd1faddd33540b4a89ae1ad3276dcb7
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spelling	oai:doaj.org-article:5fd1faddd33540b4a89ae1ad3276dcb72021-12-02T13:17:08ZUsefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis1177-5483https://doaj.org/article/5fd1faddd33540b4a89ae1ad3276dcb72020-08-01T00:00:00Zhttps://www.dovepress.com/usefulness-of-combined-measurement-of-serum-soluble-il-2r-and-angioten-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mami Ishihara, Akira Meguro, Mizuho Ishido, Masaki Takeuchi, Etsuko Shibuya, Nobuhisa Mizuki Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, JapanCorrespondence: Mami Ishihara; Akira Meguro Tel +81-45-787-2683Fax +81-45-781-9755Email mamitaiga7@gmail.com; akmeguro@yokohama-cu.ac.jpPurpose: Angiotensin-converting enzyme (ACE) is conventionally used as a biomarker in the diagnosis of uveitis associated with sarcoidosis, but its sensitivity is relatively low. In this study, we investigated whether serum soluble interleukin-2 receptor (sIL-2R) is also useful as a diagnostic marker, in addition to ACE, in the detection of uveitis associated with sarcoidosis.Patients and Methods: Data were analyzed from 126 patients with uveitis (52 sarcoidosis and 74 non-sarcoid uveitis) and 12 with primary intraocular lymphoma (PIOL) who had their serum sIL-2R and ACE levels measured.Results: Serum sIL-2R level was elevated in 69.2% of patients with sarcoid uveitis, 5.4% of those with non-sarcoid uveitis, and 16.7% of those with PIOL. The sensitivity and specificity of an elevated sIL-2R level for the detection of sarcoidosis were 69.2% and 93.0%, respectively. In contrast, serum ACE levels were elevated only in patients with sarcoid uveitis, with a sensitivity of 44.2% and specificity of 100%. Furthermore, serum sIL-2R and/or ACE level was elevated in 75.0% of patients with sarcoid uveitis, which is higher than those who had elevated serum ACE level only (44.2%, P = 0.0025). The sensitivity and specificity of elevated sIL-2R and/or ACE in detecting sarcoid uveitis were 75.0% and 93.0%, respectively. The PPV was 0.87, and the NPV was 0.86.Conclusion: Compared with the sensitivity of serum ACE levels alone, combined measurement of both serum sIL-2R and ACE levels improves sensitivity in the detection of uveitis associated with sarcoidosis. Nevertheless, serum ACE alone remains useful thanks to its high specificity in the differentiation of uveitis patients, with sarcoidosis from those without sarcoidosis.Keywords: sarcoid uveitis, soluble interleukin-2 receptors, sIL-2R, angiotensin-converting enzyme, ACE, primary intraocular lymphoma, PIOLIshihara MMeguro AIshido MTakeuchi MShibuya EMizuki NDove Medical Pressarticlesarcoid uveitissoluble interleukin-2 receptors (sil-2r)angiotensin-converting enzyme (ace)primary intraocular lymphoma (piol)OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2311-2317 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcoid uveitis soluble interleukin-2 receptors (sil-2r) angiotensin-converting enzyme (ace) primary intraocular lymphoma (piol) Ophthalmology RE1-994
spellingShingle	sarcoid uveitis soluble interleukin-2 receptors (sil-2r) angiotensin-converting enzyme (ace) primary intraocular lymphoma (piol) Ophthalmology RE1-994 Ishihara M Meguro A Ishido M Takeuchi M Shibuya E Mizuki N Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
description	Mami Ishihara, Akira Meguro, Mizuho Ishido, Masaki Takeuchi, Etsuko Shibuya, Nobuhisa Mizuki Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, JapanCorrespondence: Mami Ishihara; Akira Meguro Tel +81-45-787-2683Fax +81-45-781-9755Email mamitaiga7@gmail.com; akmeguro@yokohama-cu.ac.jpPurpose: Angiotensin-converting enzyme (ACE) is conventionally used as a biomarker in the diagnosis of uveitis associated with sarcoidosis, but its sensitivity is relatively low. In this study, we investigated whether serum soluble interleukin-2 receptor (sIL-2R) is also useful as a diagnostic marker, in addition to ACE, in the detection of uveitis associated with sarcoidosis.Patients and Methods: Data were analyzed from 126 patients with uveitis (52 sarcoidosis and 74 non-sarcoid uveitis) and 12 with primary intraocular lymphoma (PIOL) who had their serum sIL-2R and ACE levels measured.Results: Serum sIL-2R level was elevated in 69.2% of patients with sarcoid uveitis, 5.4% of those with non-sarcoid uveitis, and 16.7% of those with PIOL. The sensitivity and specificity of an elevated sIL-2R level for the detection of sarcoidosis were 69.2% and 93.0%, respectively. In contrast, serum ACE levels were elevated only in patients with sarcoid uveitis, with a sensitivity of 44.2% and specificity of 100%. Furthermore, serum sIL-2R and/or ACE level was elevated in 75.0% of patients with sarcoid uveitis, which is higher than those who had elevated serum ACE level only (44.2%, P = 0.0025). The sensitivity and specificity of elevated sIL-2R and/or ACE in detecting sarcoid uveitis were 75.0% and 93.0%, respectively. The PPV was 0.87, and the NPV was 0.86.Conclusion: Compared with the sensitivity of serum ACE levels alone, combined measurement of both serum sIL-2R and ACE levels improves sensitivity in the detection of uveitis associated with sarcoidosis. Nevertheless, serum ACE alone remains useful thanks to its high specificity in the differentiation of uveitis patients, with sarcoidosis from those without sarcoidosis.Keywords: sarcoid uveitis, soluble interleukin-2 receptors, sIL-2R, angiotensin-converting enzyme, ACE, primary intraocular lymphoma, PIOL
format	article
author	Ishihara M Meguro A Ishido M Takeuchi M Shibuya E Mizuki N
author_facet	Ishihara M Meguro A Ishido M Takeuchi M Shibuya E Mizuki N
author_sort	Ishihara M
title	Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
title_short	Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
title_full	Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
title_fullStr	Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
title_full_unstemmed	Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis
title_sort	usefulness of combined measurement of serum soluble il-2r and angiotensin-converting enzyme in the detection of uveitis associated with japanese sarcoidosis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5fd1faddd33540b4a89ae1ad3276dcb7
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Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis

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