Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial

Background: Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoc...

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Autores principales:	Congcong Zeng, Zhengzhong Yuan, Jiahui Zhu, Yintong Wang, Yongyong Xie, Ren Ye, Jinguo Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 Maxingshigan-Weijing decoction Symptom recovery Traditional Chinese medicine Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/5fd200807e3c4bebab434188afb03fec
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spelling	oai:doaj.org-article:5fd200807e3c4bebab434188afb03fec2021-12-04T04:34:09ZTherapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial2213-422010.1016/j.imr.2021.100782https://doaj.org/article/5fd200807e3c4bebab434188afb03fec2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221342202100069Xhttps://doaj.org/toc/2213-4220Background: Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoction (MWD) in treating infected patients. Methods: This study was an open-label randomized controlled trial. Inpatients with mild or moderate symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were randomly treated with routine supportive care alone or a combination of routine supportive care and MWD. The primary outcome was the rate of symptom (fever, fatigue, cough and difficulty breathing) recovery. Results: Fifty-nine inpatients were enrolled, of whom 29 received routine supportive care alone (control group) and 30 received combination therapy (treatment group). The rate of symptom recovery was significantly higher in the treatment group than in the control group. The time to recovery of fever (3 vs. 7 days), fatigue (9 vs. 12 days), coughing (9 vs. 14 days) and difficulty breathing (4.5 vs. 9.5 days) was also significantly shorter in the treatment group (all p < 0.001). The syndrome score was lower after MWD treatment. However, neither group differed in the viral assay findings, hospitalization days, medication time or the rate of conversion to severe cases. Conclusions: MWD increased the rate of symptom recovery and shortened the time to recovery of clinical symptoms without deterioration to death or critical care. These findings may provide opportunities for the use of complementary medicine in treating this infection. Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR2000030759.Congcong ZengZhengzhong YuanJiahui ZhuYintong WangYongyong XieRen YeJinguo ChengElsevierarticleCOVID-19Maxingshigan-Weijing decoctionSymptom recoveryTraditional Chinese medicineMiscellaneous systems and treatmentsRZ409.7-999ENIntegrative Medicine Research, Vol 10, Iss , Pp 100782- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Maxingshigan-Weijing decoction Symptom recovery Traditional Chinese medicine Miscellaneous systems and treatments RZ409.7-999
spellingShingle	COVID-19 Maxingshigan-Weijing decoction Symptom recovery Traditional Chinese medicine Miscellaneous systems and treatments RZ409.7-999 Congcong Zeng Zhengzhong Yuan Jiahui Zhu Yintong Wang Yongyong Xie Ren Ye Jinguo Cheng Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
description	Background: Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoction (MWD) in treating infected patients. Methods: This study was an open-label randomized controlled trial. Inpatients with mild or moderate symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were randomly treated with routine supportive care alone or a combination of routine supportive care and MWD. The primary outcome was the rate of symptom (fever, fatigue, cough and difficulty breathing) recovery. Results: Fifty-nine inpatients were enrolled, of whom 29 received routine supportive care alone (control group) and 30 received combination therapy (treatment group). The rate of symptom recovery was significantly higher in the treatment group than in the control group. The time to recovery of fever (3 vs. 7 days), fatigue (9 vs. 12 days), coughing (9 vs. 14 days) and difficulty breathing (4.5 vs. 9.5 days) was also significantly shorter in the treatment group (all p < 0.001). The syndrome score was lower after MWD treatment. However, neither group differed in the viral assay findings, hospitalization days, medication time or the rate of conversion to severe cases. Conclusions: MWD increased the rate of symptom recovery and shortened the time to recovery of clinical symptoms without deterioration to death or critical care. These findings may provide opportunities for the use of complementary medicine in treating this infection. Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR2000030759.
format	article
author	Congcong Zeng Zhengzhong Yuan Jiahui Zhu Yintong Wang Yongyong Xie Ren Ye Jinguo Cheng
author_facet	Congcong Zeng Zhengzhong Yuan Jiahui Zhu Yintong Wang Yongyong Xie Ren Ye Jinguo Cheng
author_sort	Congcong Zeng
title	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
title_short	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
title_full	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
title_fullStr	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
title_full_unstemmed	Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial
title_sort	therapeutic effects of traditional chinese medicine (maxingshigan-weijing decoction) on covid-19: an open-label randomized controlled trial
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5fd200807e3c4bebab434188afb03fec
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Therapeutic effects of traditional Chinese medicine (Maxingshigan-Weijing Decoction) on COVID-19: An open-label randomized controlled trial

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