Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis

Aims. The aim of this study was to assess the safety and diagnostic efficacy of frequency-domain optical coherence tomography (FD-OCT) in identifying functional severity of the left main coronary artery (LM) stenosis determined by fractional flow reserve (FFR). Methods and Results. 101 patients with...

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Autores principales:	Konstantina P. Bouki, Delia I. Vlad, Nikolaos Goulas, Vaia A. Lambadiari, George D. Dimitriadis, Athanasios A. Kotsakis, Kyriaki Barοutsi, Konstantinos P. Toutouzas
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi-Wiley 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5fd429317802493a9228f96adb43fa1c
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spelling	oai:doaj.org-article:5fd429317802493a9228f96adb43fa1c2021-11-29T00:57:04ZDiagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis1540-818310.1155/2021/7108284https://doaj.org/article/5fd429317802493a9228f96adb43fa1c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7108284https://doaj.org/toc/1540-8183Aims. The aim of this study was to assess the safety and diagnostic efficacy of frequency-domain optical coherence tomography (FD-OCT) in identifying functional severity of the left main coronary artery (LM) stenosis determined by fractional flow reserve (FFR). Methods and Results. 101 patients with LM lesion (20–70% diameter stenosis angiographically) underwent FFR measurement and FD-OCT imaging of the LM. The following parameters were measured by FD-OCT in the LM: reference lumen area (RLA), reference lumen diameter (RLD), minimum lumen area (MLA), minimum lumen diameter (MLD), % lumen area stenosis, and % diameter stenosis. The LM lesions were analyzable by FD-OCT in 88/101 (87.1%) patients. FFR at maximum hyperemia was ≤0.80 in 39/88 (44.3%) patients. FFR values were correlated significantly with FD-OCT-derived LM lumen parameters. An MLA cutoff value of 5.38 mm2 had the highest sensitivity and specificity of 82% and 81%, respectively, followed by an MLD of 2.43 mm (sensitivity 77%, specificity 72%) and AS of 60% (sensitivity 72%, specificity 72%) for predicting FFR <0.80. Conclusions. FD-OCT is a safe and feasible imaging technique for the assessment of LM stenosis. An FD-OCT-derived MLA of ≤5.38 mm2 strongly predicts the functional severity of an LM lesion.Konstantina P. BoukiDelia I. VladNikolaos GoulasVaia A. LambadiariGeorge D. DimitriadisAthanasios A. KotsakisKyriaki BarοutsiKonstantinos P. ToutouzasHindawi-WileyarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Interventional Cardiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Konstantina P. Bouki Delia I. Vlad Nikolaos Goulas Vaia A. Lambadiari George D. Dimitriadis Athanasios A. Kotsakis Kyriaki Barοutsi Konstantinos P. Toutouzas Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
description	Aims. The aim of this study was to assess the safety and diagnostic efficacy of frequency-domain optical coherence tomography (FD-OCT) in identifying functional severity of the left main coronary artery (LM) stenosis determined by fractional flow reserve (FFR). Methods and Results. 101 patients with LM lesion (20–70% diameter stenosis angiographically) underwent FFR measurement and FD-OCT imaging of the LM. The following parameters were measured by FD-OCT in the LM: reference lumen area (RLA), reference lumen diameter (RLD), minimum lumen area (MLA), minimum lumen diameter (MLD), % lumen area stenosis, and % diameter stenosis. The LM lesions were analyzable by FD-OCT in 88/101 (87.1%) patients. FFR at maximum hyperemia was ≤0.80 in 39/88 (44.3%) patients. FFR values were correlated significantly with FD-OCT-derived LM lumen parameters. An MLA cutoff value of 5.38 mm2 had the highest sensitivity and specificity of 82% and 81%, respectively, followed by an MLD of 2.43 mm (sensitivity 77%, specificity 72%) and AS of 60% (sensitivity 72%, specificity 72%) for predicting FFR <0.80. Conclusions. FD-OCT is a safe and feasible imaging technique for the assessment of LM stenosis. An FD-OCT-derived MLA of ≤5.38 mm2 strongly predicts the functional severity of an LM lesion.
format	article
author	Konstantina P. Bouki Delia I. Vlad Nikolaos Goulas Vaia A. Lambadiari George D. Dimitriadis Athanasios A. Kotsakis Kyriaki Barοutsi Konstantinos P. Toutouzas
author_facet	Konstantina P. Bouki Delia I. Vlad Nikolaos Goulas Vaia A. Lambadiari George D. Dimitriadis Athanasios A. Kotsakis Kyriaki Barοutsi Konstantinos P. Toutouzas
author_sort	Konstantina P. Bouki
title	Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
title_short	Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
title_full	Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
title_fullStr	Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
title_full_unstemmed	Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis
title_sort	diagnostic performance of frequency-domain optical coherence tomography to predict functionally significant left main coronary artery stenosis
publisher	Hindawi-Wiley
publishDate	2021
url	https://doaj.org/article/5fd429317802493a9228f96adb43fa1c
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Diagnostic Performance of Frequency-Domain Optical Coherence Tomography to Predict Functionally Significant Left Main Coronary Artery Stenosis

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