ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.
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Nature Portfolio
2019
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oai:doaj.org-article:5fd719ba14de49b9b63737e49dcf48782021-12-02T16:58:18ZERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP10.1038/s41467-019-11093-02041-1723https://doaj.org/article/5fd719ba14de49b9b63737e49dcf48782019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11093-0https://doaj.org/toc/2041-1723ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.Francesca BufalieriPaola InfanteFlavia BernardiMiriam CaimanoPaolo RomaniaMarta MorettiLudovica Lospinoso SeveriniJulie TalbotOmbretta MelaiuMirella TanoriLaura Di MagnoDiana BellaviaCarlo CapalboStéphanie PugetEnrico De SmaeleGianluca CanettieriDaniele GuardavaccaroLuca BusinoAngelo PeschiaroliSimonetta PazzagliaGiuseppe GianniniGerry MelinoFranco LocatelliAlberto GulinoOlivier AyraultDoriana FruciLucia Di MarcotullioNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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| language |
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| topic |
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Science Q Francesca Bufalieri Paola Infante Flavia Bernardi Miriam Caimano Paolo Romania Marta Moretti Ludovica Lospinoso Severini Julie Talbot Ombretta Melaiu Mirella Tanori Laura Di Magno Diana Bellavia Carlo Capalbo Stéphanie Puget Enrico De Smaele Gianluca Canettieri Daniele Guardavaccaro Luca Busino Angelo Peschiaroli Simonetta Pazzaglia Giuseppe Giannini Gerry Melino Franco Locatelli Alberto Gulino Olivier Ayrault Doriana Fruci Lucia Di Marcotullio ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| description |
ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability. |
| format |
article |
| author |
Francesca Bufalieri Paola Infante Flavia Bernardi Miriam Caimano Paolo Romania Marta Moretti Ludovica Lospinoso Severini Julie Talbot Ombretta Melaiu Mirella Tanori Laura Di Magno Diana Bellavia Carlo Capalbo Stéphanie Puget Enrico De Smaele Gianluca Canettieri Daniele Guardavaccaro Luca Busino Angelo Peschiaroli Simonetta Pazzaglia Giuseppe Giannini Gerry Melino Franco Locatelli Alberto Gulino Olivier Ayrault Doriana Fruci Lucia Di Marcotullio |
| author_facet |
Francesca Bufalieri Paola Infante Flavia Bernardi Miriam Caimano Paolo Romania Marta Moretti Ludovica Lospinoso Severini Julie Talbot Ombretta Melaiu Mirella Tanori Laura Di Magno Diana Bellavia Carlo Capalbo Stéphanie Puget Enrico De Smaele Gianluca Canettieri Daniele Guardavaccaro Luca Busino Angelo Peschiaroli Simonetta Pazzaglia Giuseppe Giannini Gerry Melino Franco Locatelli Alberto Gulino Olivier Ayrault Doriana Fruci Lucia Di Marcotullio |
| author_sort |
Francesca Bufalieri |
| title |
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| title_short |
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| title_full |
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| title_fullStr |
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| title_full_unstemmed |
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| title_sort |
erap1 promotes hedgehog-dependent tumorigenesis by controlling usp47-mediated degradation of βtrcp |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/5fd719ba14de49b9b63737e49dcf4878 |
| work_keys_str_mv |
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