A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion
Álvaro Sánchez-Ferro,1–4 Julián Benito-León,1–3 Alex J Mitchell,5 Félix Bermejo-Pareja1–31Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain; 2Department of Med...
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Dove Medical Press
2013
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oai:doaj.org-article:5fda08856b8547b4a517d0d71397bdca2021-12-02T03:13:11ZA review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion1176-63281178-2021https://doaj.org/article/5fda08856b8547b4a517d0d71397bdca2013-01-01T00:00:00Zhttp://www.dovepress.com/a-review-of-the-potential-therapeutic-role-of-statins-in-the-treatment-a11870https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Álvaro Sánchez-Ferro,1–4 Julián Benito-León,1–3 Alex J Mitchell,5 Félix Bermejo-Pareja1–31Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain; 2Department of Medicine, Complutense University, Madrid, Spain; 3Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain; 4Instituto de Salud Carlos III, Madrid, Spain; 5Department of Psycho-oncology, Leicestershire Partnership NHS Trust and University of Leicester, Leicester, UKAbstract: Alzheimer’s disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer’s disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer’s disease.Keywords: animal models, epidemiology, HMGCoA-inhibitors, clinical trials, prevention, cognitive functionMitchell AJBenito-León JSánchez-Ferro ABermejo-Pareja FDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 55-63 (2013) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mitchell AJ Benito-León J Sánchez-Ferro A Bermejo-Pareja F A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| description |
Álvaro Sánchez-Ferro,1–4 Julián Benito-León,1–3 Alex J Mitchell,5 Félix Bermejo-Pareja1–31Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain; 2Department of Medicine, Complutense University, Madrid, Spain; 3Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain; 4Instituto de Salud Carlos III, Madrid, Spain; 5Department of Psycho-oncology, Leicestershire Partnership NHS Trust and University of Leicester, Leicester, UKAbstract: Alzheimer’s disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer’s disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer’s disease.Keywords: animal models, epidemiology, HMGCoA-inhibitors, clinical trials, prevention, cognitive function |
| format |
article |
| author |
Mitchell AJ Benito-León J Sánchez-Ferro A Bermejo-Pareja F |
| author_facet |
Mitchell AJ Benito-León J Sánchez-Ferro A Bermejo-Pareja F |
| author_sort |
Mitchell AJ |
| title |
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| title_short |
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| title_full |
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| title_fullStr |
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| title_full_unstemmed |
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion |
| title_sort |
review of the potential therapeutic role of statins in the treatment of alzheimer’s disease: current research and opinion |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/5fda08856b8547b4a517d0d71397bdca |
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