The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

Cryptochrome 1 (CRY1) is a transcriptional coregulator associated with the circadian clock. Here the authors reveal that CRY1 is hormone-regulated, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation.

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Autores principales: Ayesha A. Shafi, Chris M. McNair, Jennifer J. McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M. Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C. Mandigo, Saswati N. Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S. Laufer, Irina A. Vasilevskaya, Matthew J. Schiewer, Michael Brunner, Felix Y. Feng, Wilbert Zwart, Karen E. Knudsen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/5fde36ecfc1c40aebc4b7e899820784f
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spelling oai:doaj.org-article:5fde36ecfc1c40aebc4b7e899820784f2021-12-02T14:01:26ZThe circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair10.1038/s41467-020-20513-52041-1723https://doaj.org/article/5fde36ecfc1c40aebc4b7e899820784f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20513-5https://doaj.org/toc/2041-1723Cryptochrome 1 (CRY1) is a transcriptional coregulator associated with the circadian clock. Here the authors reveal that CRY1 is hormone-regulated, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation.Ayesha A. ShafiChris M. McNairJennifer J. McCannMohammed AlshalalfaAnton ShostakTesa M. SeversonYanyun ZhuAndre BergmanNicolas GordonAmy C. MandigoSaswati N. ChandPeter GallagherEmanuela DylgjeriTalya S. LauferIrina A. VasilevskayaMatthew J. SchiewerMichael BrunnerFelix Y. FengWilbert ZwartKaren E. KnudsenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ayesha A. Shafi
Chris M. McNair
Jennifer J. McCann
Mohammed Alshalalfa
Anton Shostak
Tesa M. Severson
Yanyun Zhu
Andre Bergman
Nicolas Gordon
Amy C. Mandigo
Saswati N. Chand
Peter Gallagher
Emanuela Dylgjeri
Talya S. Laufer
Irina A. Vasilevskaya
Matthew J. Schiewer
Michael Brunner
Felix Y. Feng
Wilbert Zwart
Karen E. Knudsen
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
description Cryptochrome 1 (CRY1) is a transcriptional coregulator associated with the circadian clock. Here the authors reveal that CRY1 is hormone-regulated, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation.
format article
author Ayesha A. Shafi
Chris M. McNair
Jennifer J. McCann
Mohammed Alshalalfa
Anton Shostak
Tesa M. Severson
Yanyun Zhu
Andre Bergman
Nicolas Gordon
Amy C. Mandigo
Saswati N. Chand
Peter Gallagher
Emanuela Dylgjeri
Talya S. Laufer
Irina A. Vasilevskaya
Matthew J. Schiewer
Michael Brunner
Felix Y. Feng
Wilbert Zwart
Karen E. Knudsen
author_facet Ayesha A. Shafi
Chris M. McNair
Jennifer J. McCann
Mohammed Alshalalfa
Anton Shostak
Tesa M. Severson
Yanyun Zhu
Andre Bergman
Nicolas Gordon
Amy C. Mandigo
Saswati N. Chand
Peter Gallagher
Emanuela Dylgjeri
Talya S. Laufer
Irina A. Vasilevskaya
Matthew J. Schiewer
Michael Brunner
Felix Y. Feng
Wilbert Zwart
Karen E. Knudsen
author_sort Ayesha A. Shafi
title The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
title_short The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
title_full The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
title_fullStr The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
title_full_unstemmed The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
title_sort circadian cryptochrome, cry1, is a pro-tumorigenic factor that rhythmically modulates dna repair
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5fde36ecfc1c40aebc4b7e899820784f
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