Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Fidel Vila-Rodriguez,1 Donna J Lang,2 Heather Baitz,3 Kristina Gicas,3 Allen E Thorton,3 Thomas S Ehmann,1 Geoff N Smith,1 Alasdair M Barr,4 Ivan J Torres,1 Lili C Kopala,1 G William MacEwan,1 Daniel J Müller,5 James L Kennedy,5 William G Honer11Department of Psychiatry, 2Division of Neuror...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5fde6ec9924a4936bb17e131b0efc3a2 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5fde6ec9924a4936bb17e131b0efc3a2 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5fde6ec9924a4936bb17e131b0efc3a22021-12-02T00:21:57ZVerbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?1178-2021https://doaj.org/article/5fde6ec9924a4936bb17e131b0efc3a22017-12-01T00:00:00Zhttps://www.dovepress.com/verbal-memory-improvement-in-first-episode--psychosis-apoe-epsilon4-ca-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fidel Vila-Rodriguez,1 Donna J Lang,2 Heather Baitz,3 Kristina Gicas,3 Allen E Thorton,3 Thomas S Ehmann,1 Geoff N Smith,1 Alasdair M Barr,4 Ivan J Torres,1 Lili C Kopala,1 G William MacEwan,1 Daniel J Müller,5 James L Kennedy,5 William G Honer11Department of Psychiatry, 2Division of Neuroradiology, Department of Radiology, The University of British Columbia, Vancouver, 3Department of Psychology, Simon Fraser University, Burnaby, 4Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, 5Department of Psychiatry, Centre for Mental Health and Addictions, University of Toronto, Toronto, ON, CanadaBackground: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-ε4 status had a pleiotropic effect in early stages of the illness.Participants and methods: A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test – second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1–5 total recall score.Results: FEP-APOE-ε4 carriers and FEP-APOE-ε4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1–5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P<0.001) as well as an APOE-ε4 by group by time (F[4, 116.2]=2.73, P=0.033) interaction with only FEP-APOE-ε4 carriers showing improved verbal memory at follow-up.Conclusion: Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are APOE-ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia. Keywords: APOE, verbal memory, antagonistic pleiotropy, first-episode psychosis, schizophreniaVila-Rodriguez FLang DJBaitz HGicas KThornton AEEhmann TSSmith GNBarr AMTorres IJKopala LCMacEwan GWMüller DJKennedy JLHoner WGDove Medical PressarticleAPOEverbal memoryantagonistic pleiotropyfirst episode psychosisschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2945-2953 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
APOE verbal memory antagonistic pleiotropy first episode psychosis schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
APOE verbal memory antagonistic pleiotropy first episode psychosis schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Vila-Rodriguez F Lang DJ Baitz H Gicas K Thornton AE Ehmann TS Smith GN Barr AM Torres IJ Kopala LC MacEwan GW Müller DJ Kennedy JL Honer WG Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| description |
Fidel Vila-Rodriguez,1 Donna J Lang,2 Heather Baitz,3 Kristina Gicas,3 Allen E Thorton,3 Thomas S Ehmann,1 Geoff N Smith,1 Alasdair M Barr,4 Ivan J Torres,1 Lili C Kopala,1 G William MacEwan,1 Daniel J Müller,5 James L Kennedy,5 William G Honer11Department of Psychiatry, 2Division of Neuroradiology, Department of Radiology, The University of British Columbia, Vancouver, 3Department of Psychology, Simon Fraser University, Burnaby, 4Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, 5Department of Psychiatry, Centre for Mental Health and Addictions, University of Toronto, Toronto, ON, CanadaBackground: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-ε4 status had a pleiotropic effect in early stages of the illness.Participants and methods: A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test – second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1–5 total recall score.Results: FEP-APOE-ε4 carriers and FEP-APOE-ε4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1–5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P<0.001) as well as an APOE-ε4 by group by time (F[4, 116.2]=2.73, P=0.033) interaction with only FEP-APOE-ε4 carriers showing improved verbal memory at follow-up.Conclusion: Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are APOE-ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia. Keywords: APOE, verbal memory, antagonistic pleiotropy, first-episode psychosis, schizophrenia |
| format |
article |
| author |
Vila-Rodriguez F Lang DJ Baitz H Gicas K Thornton AE Ehmann TS Smith GN Barr AM Torres IJ Kopala LC MacEwan GW Müller DJ Kennedy JL Honer WG |
| author_facet |
Vila-Rodriguez F Lang DJ Baitz H Gicas K Thornton AE Ehmann TS Smith GN Barr AM Torres IJ Kopala LC MacEwan GW Müller DJ Kennedy JL Honer WG |
| author_sort |
Vila-Rodriguez F |
| title |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| title_short |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| title_full |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| title_fullStr |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| title_full_unstemmed |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
| title_sort |
verbal memory improvement in first-episode psychosis apoe-ε4 carriers: a pleiotropic effect? |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/5fde6ec9924a4936bb17e131b0efc3a2 |
| work_keys_str_mv |
AT vilarodriguezf verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT langdj verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT baitzh verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT gicask verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT thorntonae verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT ehmannts verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT smithgn verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT barram verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT torresij verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT kopalalc verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT macewangw verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT mullerdj verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT kennedyjl verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect AT honerwg verbalmemoryimprovementinfirstepisodepsychosisapoeepsilon4carriersapleiotropiceffect |
| _version_ |
1718403802591133696 |