A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may confer a selected advantage to edited cells.
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Nature Portfolio
2021
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oai:doaj.org-article:5fe16eb955dc4e7db09618e84c5923882021-11-14T12:34:13ZA systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing10.1038/s41467-021-26788-62041-1723https://doaj.org/article/5fe16eb955dc4e7db09618e84c5923882021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26788-6https://doaj.org/toc/2041-1723CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may confer a selected advantage to edited cells.Sanju SinhaKarina BarbosaKuoyuan ChengMark D. M. LeisersonPrashant JainAnagha DeshpandeDavid M. WilsonBríd M. RyanJi LuoZe’ev A. RonaiJoo Sang LeeAniruddha J. DeshpandeEytan RuppinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sanju Sinha Karina Barbosa Kuoyuan Cheng Mark D. M. Leiserson Prashant Jain Anagha Deshpande David M. Wilson Bríd M. Ryan Ji Luo Ze’ev A. Ronai Joo Sang Lee Aniruddha J. Deshpande Eytan Ruppin A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| description |
CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may confer a selected advantage to edited cells. |
| format |
article |
| author |
Sanju Sinha Karina Barbosa Kuoyuan Cheng Mark D. M. Leiserson Prashant Jain Anagha Deshpande David M. Wilson Bríd M. Ryan Ji Luo Ze’ev A. Ronai Joo Sang Lee Aniruddha J. Deshpande Eytan Ruppin |
| author_facet |
Sanju Sinha Karina Barbosa Kuoyuan Cheng Mark D. M. Leiserson Prashant Jain Anagha Deshpande David M. Wilson Bríd M. Ryan Ji Luo Ze’ev A. Ronai Joo Sang Lee Aniruddha J. Deshpande Eytan Ruppin |
| author_sort |
Sanju Sinha |
| title |
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| title_short |
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| title_full |
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| title_fullStr |
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| title_full_unstemmed |
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing |
| title_sort |
systematic genome-wide mapping of oncogenic mutation selection during crispr-cas9 genome editing |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5fe16eb955dc4e7db09618e84c592388 |
| work_keys_str_mv |
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