Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial

Abstract Warfarin therapy can significantly affect patients’ quality of life and cause therapy discontinuation. This study aimed to investigate the effect of the pharmacists’ interventions on the health-related quality of life (HRQoL) in older rural patients on warfarin therapy. Eligible older patie...

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Autores principales:	Slaven Falamić, Marko Lucijanić, Maja Ortner-Hadžiabdić, Srećko Marušić, Vesna Bačić-Vrca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fe24ac8cd6244dd950d8d32a9b6deca
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spelling	oai:doaj.org-article:5fe24ac8cd6244dd950d8d32a9b6deca2021-11-14T12:20:34ZPharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial10.1038/s41598-021-01394-02045-2322https://doaj.org/article/5fe24ac8cd6244dd950d8d32a9b6deca2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01394-0https://doaj.org/toc/2045-2322Abstract Warfarin therapy can significantly affect patients’ quality of life and cause therapy discontinuation. This study aimed to investigate the effect of the pharmacists’ interventions on the health-related quality of life (HRQoL) in older rural patients on warfarin therapy. Eligible older patients from rural area of Croatian province Slavonia were randomized into the intervention and control groups and followed for six months. Repeated education and a follow-up plan were provided to the participants in the intervention group, and if needed, the pharmacist intervened to optimize warfarin therapy. Secondary analysis on HRQoL data are presented here. Main outcome measure was Duke anticoagulation satisfactions scale questionnaire score. In total, 131 participants finished the study (median age 73 years; 51.1% male). Participants in the intervention group scored significantly lower (median being 86.5 and 66.0 in the control and intervention groups, respectively; p < 0,001), indicating higher HRQoL. Adverse drug reactions and pharmacist’s intervention were identified as predictive factors for patients’ HRQoL (r2 = 65.5%, P < 0.001). The study demonstrated that community pharmacist’s interventions can improve HRQoL of older patients taking warfarin what is of particular significance for patients living in rural areas with less accessible healthcare and lower socio-economic status. Clinicaltrials.gov (ID: NCT03212898), 11/07/2017, retrospectively registered.Slaven FalamićMarko LucijanićMaja Ortner-HadžiabdićSrećko MarušićVesna Bačić-VrcaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Slaven Falamić Marko Lucijanić Maja Ortner-Hadžiabdić Srećko Marušić Vesna Bačić-Vrca Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
description	Abstract Warfarin therapy can significantly affect patients’ quality of life and cause therapy discontinuation. This study aimed to investigate the effect of the pharmacists’ interventions on the health-related quality of life (HRQoL) in older rural patients on warfarin therapy. Eligible older patients from rural area of Croatian province Slavonia were randomized into the intervention and control groups and followed for six months. Repeated education and a follow-up plan were provided to the participants in the intervention group, and if needed, the pharmacist intervened to optimize warfarin therapy. Secondary analysis on HRQoL data are presented here. Main outcome measure was Duke anticoagulation satisfactions scale questionnaire score. In total, 131 participants finished the study (median age 73 years; 51.1% male). Participants in the intervention group scored significantly lower (median being 86.5 and 66.0 in the control and intervention groups, respectively; p < 0,001), indicating higher HRQoL. Adverse drug reactions and pharmacist’s intervention were identified as predictive factors for patients’ HRQoL (r2 = 65.5%, P < 0.001). The study demonstrated that community pharmacist’s interventions can improve HRQoL of older patients taking warfarin what is of particular significance for patients living in rural areas with less accessible healthcare and lower socio-economic status. Clinicaltrials.gov (ID: NCT03212898), 11/07/2017, retrospectively registered.
format	article
author	Slaven Falamić Marko Lucijanić Maja Ortner-Hadžiabdić Srećko Marušić Vesna Bačić-Vrca
author_facet	Slaven Falamić Marko Lucijanić Maja Ortner-Hadžiabdić Srećko Marušić Vesna Bačić-Vrca
author_sort	Slaven Falamić
title	Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
title_short	Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
title_full	Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
title_fullStr	Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
title_full_unstemmed	Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
title_sort	pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5fe24ac8cd6244dd950d8d32a9b6deca
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Pharmacists’ interventions improve health-related quality of life of rural older person on warfarin: a randomized controlled trial

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