Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.

In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make th...

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Autores principales:	Hui-Xian Mei, Liang Cheng, Jia Tang, Zi-Ying Fu, Xin Wang, Philip H-S Jen, Qi-Cai Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fe29b3154c84e86bda30d84bf0ccbda
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id	oai:doaj.org-article:5fe29b3154c84e86bda30d84bf0ccbda
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spelling	oai:doaj.org-article:5fe29b3154c84e86bda30d84bf0ccbda2021-11-18T07:11:19ZBilateral collicular interaction: modulation of auditory signal processing in amplitude domain.1932-620310.1371/journal.pone.0041311https://doaj.org/article/5fe29b3154c84e86bda30d84bf0ccbda2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22911778/?tool=EBIhttps://doaj.org/toc/1932-6203In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.Hui-Xian MeiLiang ChengJia TangZi-Ying FuXin WangPhilip H-S JenQi-Cai ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41311 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui-Xian Mei Liang Cheng Jia Tang Zi-Ying Fu Xin Wang Philip H-S Jen Qi-Cai Chen Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
description	In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.
format	article
author	Hui-Xian Mei Liang Cheng Jia Tang Zi-Ying Fu Xin Wang Philip H-S Jen Qi-Cai Chen
author_facet	Hui-Xian Mei Liang Cheng Jia Tang Zi-Ying Fu Xin Wang Philip H-S Jen Qi-Cai Chen
author_sort	Hui-Xian Mei
title	Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
title_short	Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
title_full	Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
title_fullStr	Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
title_full_unstemmed	Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
title_sort	bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5fe29b3154c84e86bda30d84bf0ccbda
work_keys_str_mv	AT huixianmei bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT liangcheng bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT jiatang bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT ziyingfu bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT xinwang bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT philiphsjen bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain AT qicaichen bilateralcollicularinteractionmodulationofauditorysignalprocessinginamplitudedomain
_version_	1718423789645070336

Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.

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