A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

The Polycomb Repressive-Deubiquitinase (PR-DUB) complex is responsible for the removal of the ubiquitin epigenetic modification from Histone 2A. Here the authors describe the structure of the Drosophila PR-DUB complex, providing new insight into its regulation and how cancer-associated mutations dis...

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Autores principales:	Martina Foglizzo, Adam J. Middleton, Abigail E. Burgess, Jennifer M. Crowther, Renwick C. J. Dobson, James M. Murphy, Catherine L. Day, Peter D. Mace
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5fe6531411b6437bb98f283f88b4a26c
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id	oai:doaj.org-article:5fe6531411b6437bb98f283f88b4a26c
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spelling	oai:doaj.org-article:5fe6531411b6437bb98f283f88b4a26c2021-12-02T16:56:57ZA bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes10.1038/s41467-018-06186-12041-1723https://doaj.org/article/5fe6531411b6437bb98f283f88b4a26c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06186-1https://doaj.org/toc/2041-1723The Polycomb Repressive-Deubiquitinase (PR-DUB) complex is responsible for the removal of the ubiquitin epigenetic modification from Histone 2A. Here the authors describe the structure of the Drosophila PR-DUB complex, providing new insight into its regulation and how cancer-associated mutations disrupt PR-DUB activity.Martina FoglizzoAdam J. MiddletonAbigail E. BurgessJennifer M. CrowtherRenwick C. J. DobsonJames M. MurphyCatherine L. DayPeter D. MaceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Foglizzo Adam J. Middleton Abigail E. Burgess Jennifer M. Crowther Renwick C. J. Dobson James M. Murphy Catherine L. Day Peter D. Mace A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
description	The Polycomb Repressive-Deubiquitinase (PR-DUB) complex is responsible for the removal of the ubiquitin epigenetic modification from Histone 2A. Here the authors describe the structure of the Drosophila PR-DUB complex, providing new insight into its regulation and how cancer-associated mutations disrupt PR-DUB activity.
format	article
author	Martina Foglizzo Adam J. Middleton Abigail E. Burgess Jennifer M. Crowther Renwick C. J. Dobson James M. Murphy Catherine L. Day Peter D. Mace
author_facet	Martina Foglizzo Adam J. Middleton Abigail E. Burgess Jennifer M. Crowther Renwick C. J. Dobson James M. Murphy Catherine L. Day Peter D. Mace
author_sort	Martina Foglizzo
title	A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
title_short	A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
title_full	A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
title_fullStr	A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
title_full_unstemmed	A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
title_sort	bidentate polycomb repressive-deubiquitinase complex is required for efficient activity on nucleosomes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5fe6531411b6437bb98f283f88b4a26c
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A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

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