Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges

Marie Bruyneel,1 Thomas Sersté2,3 1Sleep Unit, Department of Pneumology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium; 2Department of Hepato-gastroenterology, Centre Hospitalier Universitaire Saint Pierre, Université...

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Autores principales:	Bruyneel M, Sersté T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	sleep disorders hepatic encephalopathy liver cirrhosis excessive daytime sleepiness circadian rhythm insomnia Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/5fe7af6078e64236949489466ea361ad
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spelling	oai:doaj.org-article:5fe7af6078e64236949489466ea361ad2021-12-02T03:08:04ZSleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges1179-1608https://doaj.org/article/5fe7af6078e64236949489466ea361ad2018-11-01T00:00:00Zhttps://www.dovepress.com/sleep-disturbances-in-patients-with-liver-cirrhosis-prevalence-impact--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Marie Bruyneel,1 Thomas Sersté2,3 1Sleep Unit, Department of Pneumology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium; 2Department of Hepato-gastroenterology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium; 3Liver Transplantation Unit, Department of Hepato-gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium Abstract: Sleep–wake disturbances are common in liver cirrhosis and associated with impaired quality of life. The most common abnormalities are insomnia (difficulties falling asleep and maintaining sleep, or unrefreshing sleep), excessive daytime sleepiness, and sleep–wake inversion (disturbances of circadian rhythmicity). The underlying pathophysiological mechanisms for sleep disturbances in cirrhosis are complex and may include disturbed metabolism of melatonin and glucose, alterations in thermoregulation, and altered ghrelin secretion profiles. Sleep–wake abnormalities are related to the presence of hepatic encephalopathy (HE) and improvement in sleep parameters can be observed when HE is properly managed. A few non-specific treatments for sleep–wake abnormalities have been tried with encouraging results for hydroxyzine and modafinil. However, due to the potential for medication toxicity in these disabled patients, further studies are needed to address the potential role of non-drug therapies in this population (eg, cognitive behavioral therapy, mindfulness, yoga) that have demonstrated usefulness in insomnia disorders. Keywords: sleep disorders, hepatic encephalopathy, liver cirrhosis, excessive daytime sleepiness, circadian rhythm, insomnia Bruyneel MSersté TDove Medical Pressarticlesleep disordershepatic encephalopathyliver cirrhosisexcessive daytime sleepinesscircadian rhythminsomniaPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 10, Pp 369-375 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep disorders hepatic encephalopathy liver cirrhosis excessive daytime sleepiness circadian rhythm insomnia Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	sleep disorders hepatic encephalopathy liver cirrhosis excessive daytime sleepiness circadian rhythm insomnia Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Bruyneel M Sersté T Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
description	Marie Bruyneel,1 Thomas Sersté2,3 1Sleep Unit, Department of Pneumology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium; 2Department of Hepato-gastroenterology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium; 3Liver Transplantation Unit, Department of Hepato-gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium Abstract: Sleep–wake disturbances are common in liver cirrhosis and associated with impaired quality of life. The most common abnormalities are insomnia (difficulties falling asleep and maintaining sleep, or unrefreshing sleep), excessive daytime sleepiness, and sleep–wake inversion (disturbances of circadian rhythmicity). The underlying pathophysiological mechanisms for sleep disturbances in cirrhosis are complex and may include disturbed metabolism of melatonin and glucose, alterations in thermoregulation, and altered ghrelin secretion profiles. Sleep–wake abnormalities are related to the presence of hepatic encephalopathy (HE) and improvement in sleep parameters can be observed when HE is properly managed. A few non-specific treatments for sleep–wake abnormalities have been tried with encouraging results for hydroxyzine and modafinil. However, due to the potential for medication toxicity in these disabled patients, further studies are needed to address the potential role of non-drug therapies in this population (eg, cognitive behavioral therapy, mindfulness, yoga) that have demonstrated usefulness in insomnia disorders. Keywords: sleep disorders, hepatic encephalopathy, liver cirrhosis, excessive daytime sleepiness, circadian rhythm, insomnia
format	article
author	Bruyneel M Sersté T
author_facet	Bruyneel M Sersté T
author_sort	Bruyneel M
title	Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
title_short	Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
title_full	Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
title_fullStr	Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
title_full_unstemmed	Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
title_sort	sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5fe7af6078e64236949489466ea361ad
work_keys_str_mv	AT bruyneelm sleepdisturbancesinpatientswithlivercirrhosisprevalenceimpactandmanagementchallenges AT serstet sleepdisturbancesinpatientswithlivercirrhosisprevalenceimpactandmanagementchallenges
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Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges

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