The prevalence of thalassemia in mainland China: evidence from epidemiological surveys

Abstract Comprehensive data regarding the epidemiology and prevalence of thalassemia in mainland China are lacking. To assess the prevalence of thalassemia, we performed a meta-analysis including 16 articles published from 1981 to 2015. The overall prevalence of α-thalassemia, β-thalassemia and α + ...

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Autores principales:	Ketong Lai, Guifeng Huang, Li Su, Yunyan He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fe99403708b4a458e51ee0db8191f6a
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spelling	oai:doaj.org-article:5fe99403708b4a458e51ee0db8191f6a2021-12-02T15:05:14ZThe prevalence of thalassemia in mainland China: evidence from epidemiological surveys10.1038/s41598-017-00967-22045-2322https://doaj.org/article/5fe99403708b4a458e51ee0db8191f6a2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00967-2https://doaj.org/toc/2045-2322Abstract Comprehensive data regarding the epidemiology and prevalence of thalassemia in mainland China are lacking. To assess the prevalence of thalassemia, we performed a meta-analysis including 16 articles published from 1981 to 2015. The overall prevalence of α-thalassemia, β-thalassemia and α + β-thalassemia was 7.88%, 2.21% and 0.48%, respectively. Trends in thalassemia prevalence in mainland China were not steady; a prevalence map based on a geographic information system (GIS) showed that the geographic distribution of thalassemia was highest in the south of China and decreased from south to north. Additionally, the most common α- and β-globin gene mutation was --SEA and CD41/42, respectively. The current study provides valuable information regarding epidemiology and intervention and supports the planning, implementation and management of prevention programmes for public health.Ketong LaiGuifeng HuangLi SuYunyan HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ketong Lai Guifeng Huang Li Su Yunyan He The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
description	Abstract Comprehensive data regarding the epidemiology and prevalence of thalassemia in mainland China are lacking. To assess the prevalence of thalassemia, we performed a meta-analysis including 16 articles published from 1981 to 2015. The overall prevalence of α-thalassemia, β-thalassemia and α + β-thalassemia was 7.88%, 2.21% and 0.48%, respectively. Trends in thalassemia prevalence in mainland China were not steady; a prevalence map based on a geographic information system (GIS) showed that the geographic distribution of thalassemia was highest in the south of China and decreased from south to north. Additionally, the most common α- and β-globin gene mutation was --SEA and CD41/42, respectively. The current study provides valuable information regarding epidemiology and intervention and supports the planning, implementation and management of prevention programmes for public health.
format	article
author	Ketong Lai Guifeng Huang Li Su Yunyan He
author_facet	Ketong Lai Guifeng Huang Li Su Yunyan He
author_sort	Ketong Lai
title	The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
title_short	The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
title_full	The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
title_fullStr	The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
title_full_unstemmed	The prevalence of thalassemia in mainland China: evidence from epidemiological surveys
title_sort	prevalence of thalassemia in mainland china: evidence from epidemiological surveys
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5fe99403708b4a458e51ee0db8191f6a
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The prevalence of thalassemia in mainland China: evidence from epidemiological surveys

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