Modern possibilities for using stem cells in diabetes mellitus
Diabetes mellitus (DM) is characterised by relative or absolute insulin deficiency. The currently available treatment methods for DM cannot provide normal blood glucose level without hypo- or hyperglycaemia episodes, thus failing to completely prevent the development of diabetic complications. Repla...
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Endocrinology Research Centre
2014
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oai:doaj.org-article:5fea63dcb79f4622be035a7dd28afd1c2021-11-14T09:00:19ZModern possibilities for using stem cells in diabetes mellitus2072-03512072-037810.14341/DM2014220-28https://doaj.org/article/5fea63dcb79f4622be035a7dd28afd1c2014-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6425https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Diabetes mellitus (DM) is characterised by relative or absolute insulin deficiency. The currently available treatment methods for DM cannot provide normal blood glucose level without hypo- or hyperglycaemia episodes, thus failing to completely prevent the development of diabetic complications. Replacement of ?-cells (transplantation of the pancreas or ?-cells) is accompanied by complications and requires life-long immunosuppressive therapy that is not always followed by restoration of insulin independence; there is also a substantial deficit of donors. Stem cells do not cause such negative effects and can be used in therapy to avoid such problems. Allogeneic stem cell transplantation is complicated by immune rejection of a transplant, whereas the use of embryonic stem cells is associated with ethical concerns, complicated cell line selection, and risk of teratoma formation. The present review focuses on therapeutic pathways of autologous transplantation of tissue stem cells in order to restore the ?-cell pool, for immune reconstitution and modulation of the immune response in DM patients.Ivan Ivanovich DedovIgor Andreevich LisukovDmitry Nikitich LaptevEndocrinology Research Centrearticlediabetes mellitusbeta-cellsstem cellsumbilical cord bloodhaematopoietic cellsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 2, Pp 20-28 (2014) |
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diabetes mellitus beta-cells stem cells umbilical cord blood haematopoietic cells Nutritional diseases. Deficiency diseases RC620-627 |
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diabetes mellitus beta-cells stem cells umbilical cord blood haematopoietic cells Nutritional diseases. Deficiency diseases RC620-627 Ivan Ivanovich Dedov Igor Andreevich Lisukov Dmitry Nikitich Laptev Modern possibilities for using stem cells in diabetes mellitus |
| description |
Diabetes mellitus (DM) is characterised by relative or absolute insulin deficiency. The currently available treatment methods for DM cannot provide normal blood glucose level without hypo- or hyperglycaemia episodes, thus failing to completely prevent the development of diabetic complications. Replacement of ?-cells (transplantation of the pancreas or ?-cells) is accompanied by complications and requires life-long immunosuppressive therapy that is not always followed by restoration of insulin independence; there is also a substantial deficit of donors. Stem cells do not cause such negative effects and can be used in therapy to avoid such problems. Allogeneic stem cell transplantation is complicated by immune rejection of a transplant, whereas the use of embryonic stem cells is associated with ethical concerns, complicated cell line selection, and risk of teratoma formation. The present review focuses on therapeutic pathways of autologous transplantation of tissue stem cells in order to restore the ?-cell pool, for immune reconstitution and modulation of the immune response in DM patients. |
| format |
article |
| author |
Ivan Ivanovich Dedov Igor Andreevich Lisukov Dmitry Nikitich Laptev |
| author_facet |
Ivan Ivanovich Dedov Igor Andreevich Lisukov Dmitry Nikitich Laptev |
| author_sort |
Ivan Ivanovich Dedov |
| title |
Modern possibilities for using stem cells in diabetes mellitus |
| title_short |
Modern possibilities for using stem cells in diabetes mellitus |
| title_full |
Modern possibilities for using stem cells in diabetes mellitus |
| title_fullStr |
Modern possibilities for using stem cells in diabetes mellitus |
| title_full_unstemmed |
Modern possibilities for using stem cells in diabetes mellitus |
| title_sort |
modern possibilities for using stem cells in diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2014 |
| url |
https://doaj.org/article/5fea63dcb79f4622be035a7dd28afd1c |
| work_keys_str_mv |
AT ivanivanovichdedov modernpossibilitiesforusingstemcellsindiabetesmellitus AT igorandreevichlisukov modernpossibilitiesforusingstemcellsindiabetesmellitus AT dmitrynikitichlaptev modernpossibilitiesforusingstemcellsindiabetesmellitus |
| _version_ |
1718429531073675264 |