Current clinical application of deep-brain stimulation for essential tremor

Amit Chopra, Bryan T Klassen, Matt Stead Department of Neurology, Mayo Clinic, Rochester, MN, USA Background: Deep-brain stimulation (DBS) is an established treatment for medically refractory essential tremor (ET). This article reviews the current evidence supporting the efficacy and safety of DBS t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chopra A, Klassen BT, Stead M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5fedbc2d36ef413581fa74ce4e4b7e38
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5fedbc2d36ef413581fa74ce4e4b7e38
record_format	dspace
spelling	oai:doaj.org-article:5fedbc2d36ef413581fa74ce4e4b7e382021-12-02T04:24:18ZCurrent clinical application of deep-brain stimulation for essential tremor1176-63281178-2021https://doaj.org/article/5fedbc2d36ef413581fa74ce4e4b7e382013-12-01T00:00:00Zhttp://www.dovepress.com/current-clinical-application-of-deep-brain-stimulation-for-essential-t-a15141https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Amit Chopra, Bryan T Klassen, Matt Stead Department of Neurology, Mayo Clinic, Rochester, MN, USA Background: Deep-brain stimulation (DBS) is an established treatment for medically refractory essential tremor (ET). This article reviews the current evidence supporting the efficacy and safety of DBS targets, including the ventral intermediate (VIM) nucleus and posterior subthalamic area (PSA) in treatment of ET. Methods: A structured PubMed search was performed through December 2012 with keywords "deep brain stimulation (DBS)," "essential tremor (ET)," "ventral intermediate (VIM) nucleus," "posterior subthalamic area (PSA)," "safety," and "efficacy." Results: Based on level IV evidence, both VIM and PSA DBS targets appear to be safe and efficacious in ET patients in tremor reduction and improving activities of daily living, though the literature on PSA DBS is limited in terms of bilateral stimulation and long-term follow-up. DBS-related adverse effects are typically mild and stimulation-related. Hardware-related complications after DBS may not be uncommon, and often require additional surgical procedures. Few studies assessed quality-of-life and cognition outcomes in ET patients undergoing DBS stimulation. Conclusion: DBS appears to be a safe and effective treatment for medically refractory ET. More systematic studies comparing VIM and PSA targets are needed to ascertain the most safe and effective DBS treatment for medically refractory ET. More research is warranted to assess quality-of-life and cognition outcomes in ET patients undergoing DBS. Keywords: deep-brain stimulation (DBS), essential tremor (ET), ventral intermediate (VIM) nucleus, posterior subthalamic area (PSA), safety, efficacyChopra AKlassen BTStead MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1859-1865 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chopra A Klassen BT Stead M Current clinical application of deep-brain stimulation for essential tremor
description	Amit Chopra, Bryan T Klassen, Matt Stead Department of Neurology, Mayo Clinic, Rochester, MN, USA Background: Deep-brain stimulation (DBS) is an established treatment for medically refractory essential tremor (ET). This article reviews the current evidence supporting the efficacy and safety of DBS targets, including the ventral intermediate (VIM) nucleus and posterior subthalamic area (PSA) in treatment of ET. Methods: A structured PubMed search was performed through December 2012 with keywords "deep brain stimulation (DBS)," "essential tremor (ET)," "ventral intermediate (VIM) nucleus," "posterior subthalamic area (PSA)," "safety," and "efficacy." Results: Based on level IV evidence, both VIM and PSA DBS targets appear to be safe and efficacious in ET patients in tremor reduction and improving activities of daily living, though the literature on PSA DBS is limited in terms of bilateral stimulation and long-term follow-up. DBS-related adverse effects are typically mild and stimulation-related. Hardware-related complications after DBS may not be uncommon, and often require additional surgical procedures. Few studies assessed quality-of-life and cognition outcomes in ET patients undergoing DBS stimulation. Conclusion: DBS appears to be a safe and effective treatment for medically refractory ET. More systematic studies comparing VIM and PSA targets are needed to ascertain the most safe and effective DBS treatment for medically refractory ET. More research is warranted to assess quality-of-life and cognition outcomes in ET patients undergoing DBS. Keywords: deep-brain stimulation (DBS), essential tremor (ET), ventral intermediate (VIM) nucleus, posterior subthalamic area (PSA), safety, efficacy
format	article
author	Chopra A Klassen BT Stead M
author_facet	Chopra A Klassen BT Stead M
author_sort	Chopra A
title	Current clinical application of deep-brain stimulation for essential tremor
title_short	Current clinical application of deep-brain stimulation for essential tremor
title_full	Current clinical application of deep-brain stimulation for essential tremor
title_fullStr	Current clinical application of deep-brain stimulation for essential tremor
title_full_unstemmed	Current clinical application of deep-brain stimulation for essential tremor
title_sort	current clinical application of deep-brain stimulation for essential tremor
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/5fedbc2d36ef413581fa74ce4e4b7e38
work_keys_str_mv	AT chopraa currentclinicalapplicationofdeepbrainstimulationforessentialtremor AT klassenbt currentclinicalapplicationofdeepbrainstimulationforessentialtremor AT steadm currentclinicalapplicationofdeepbrainstimulationforessentialtremor
_version_	1718401247691669504

Current clinical application of deep-brain stimulation for essential tremor

Ejemplares similares