Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites

The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points...

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Autores principales: Xianzhuang Liu, Xiangyang Guo, Liling Niu, Xixia Li, Fei Sun, Junjie Hu, Xiangming Wang, Kang Shen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5fedf1bfc9bf4bae9dd14b5234f42558
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spelling oai:doaj.org-article:5fedf1bfc9bf4bae9dd14b5234f425582021-12-02T16:58:13ZAtlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites10.1038/s41467-019-08478-62041-1723https://doaj.org/article/5fedf1bfc9bf4bae9dd14b5234f425582019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08478-6https://doaj.org/toc/2041-1723The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points and abnormalities in protein homeostasis.Xianzhuang LiuXiangyang GuoLiling NiuXixia LiFei SunJunjie HuXiangming WangKang ShenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xianzhuang Liu
Xiangyang Guo
Liling Niu
Xixia Li
Fei Sun
Junjie Hu
Xiangming Wang
Kang Shen
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
description The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points and abnormalities in protein homeostasis.
format article
author Xianzhuang Liu
Xiangyang Guo
Liling Niu
Xixia Li
Fei Sun
Junjie Hu
Xiangming Wang
Kang Shen
author_facet Xianzhuang Liu
Xiangyang Guo
Liling Niu
Xixia Li
Fei Sun
Junjie Hu
Xiangming Wang
Kang Shen
author_sort Xianzhuang Liu
title Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
title_short Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
title_full Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
title_fullStr Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
title_full_unstemmed Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
title_sort atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/5fedf1bfc9bf4bae9dd14b5234f42558
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AT feisun atlastin1regulatesmorphologyandfunctionofendoplasmicreticulumindendrites
AT junjiehu atlastin1regulatesmorphologyandfunctionofendoplasmicreticulumindendrites
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