Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points...
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Nature Portfolio
2019
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oai:doaj.org-article:5fedf1bfc9bf4bae9dd14b5234f425582021-12-02T16:58:13ZAtlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites10.1038/s41467-019-08478-62041-1723https://doaj.org/article/5fedf1bfc9bf4bae9dd14b5234f425582019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08478-6https://doaj.org/toc/2041-1723The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points and abnormalities in protein homeostasis.Xianzhuang LiuXiangyang GuoLiling NiuXixia LiFei SunJunjie HuXiangming WangKang ShenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Xianzhuang Liu Xiangyang Guo Liling Niu Xixia Li Fei Sun Junjie Hu Xiangming Wang Kang Shen Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
description |
The molecular mechanisms that achieve ER morphology in neurites are not well understood. This study uses a forward genetic approach to demonstrate that atln-1 is required for neuronal ER morphology and that C. elegans atln-1 mutants exhibit defects in mitochondria fission at dendritic branch points and abnormalities in protein homeostasis. |
format |
article |
author |
Xianzhuang Liu Xiangyang Guo Liling Niu Xixia Li Fei Sun Junjie Hu Xiangming Wang Kang Shen |
author_facet |
Xianzhuang Liu Xiangyang Guo Liling Niu Xixia Li Fei Sun Junjie Hu Xiangming Wang Kang Shen |
author_sort |
Xianzhuang Liu |
title |
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
title_short |
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
title_full |
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
title_fullStr |
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
title_full_unstemmed |
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
title_sort |
atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/5fedf1bfc9bf4bae9dd14b5234f42558 |
work_keys_str_mv |
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1718382388564721664 |