An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China
Abstract Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body mass index (BMI) patients maintain during antiretroviral therapy (ART). We aimed t...
Guardado en:
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5fee4f740636457d8666096c32c222f6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:5fee4f740636457d8666096c32c222f6 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:5fee4f740636457d8666096c32c222f62021-12-02T15:08:47ZAn optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China10.1038/s41598-019-44279-z2045-2322https://doaj.org/article/5fee4f740636457d8666096c32c222f62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44279-zhttps://doaj.org/toc/2045-2322Abstract Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body mass index (BMI) patients maintain during antiretroviral therapy (ART). We aimed to evaluate associations of the BMI values pre-ART and during the entire ART duration with mortality among HIV-positive individuals. In total, 5101 HIV/AIDS patients, including 1439 (28.2%) underweight, 3047 (59.7%) normal-weight, 548 (10.7%) overweight and 67 (1.3%) obese patients, were included in this cohort. The cumulative mortality of underweight, normal-weight, and overweight were 2.4/100 person-years (95% CI 1.9–2.9), 1.1/100 person-years (95% CI 0.9–1.3), and 0.5/100 person-years (95% CI 0.1–0.9), respectively. Cumulative mortality was lower in both the normal-weight and overweight populations than in the underweight population, with an adjusted hazard ratio (AHR) of 0.5 (95% CI 0.4–0.7, p < 0.001) and 0.3 (95% CI 0.1–0.6, p = 0.002), respectively. Additionally, in the 1176 patients with available viral load data, there was significant difference between the underweight and normal-weight groups after adjustment for all factors, including viral load (p = 0.031). This result suggests that HIV-infected patients in Guangxi maintaining a BMI of 19–28 kg/m2, especially 24–28 kg/m2, have a reduced risk of death.Junjun JiangXionglin QinHuifang LiuSirun MengAbu S. AbdullahJinping HuangChunwei QinYanfen LiuYunxuan HuangFengxiang QinJiegang HuangNing ZangBingyu LiangChuanyi NingYanyan LiaoHao LiangFengyao WuLi YeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Junjun Jiang Xionglin Qin Huifang Liu Sirun Meng Abu S. Abdullah Jinping Huang Chunwei Qin Yanfen Liu Yunxuan Huang Fengxiang Qin Jiegang Huang Ning Zang Bingyu Liang Chuanyi Ning Yanyan Liao Hao Liang Fengyao Wu Li Ye An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
description |
Abstract Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body mass index (BMI) patients maintain during antiretroviral therapy (ART). We aimed to evaluate associations of the BMI values pre-ART and during the entire ART duration with mortality among HIV-positive individuals. In total, 5101 HIV/AIDS patients, including 1439 (28.2%) underweight, 3047 (59.7%) normal-weight, 548 (10.7%) overweight and 67 (1.3%) obese patients, were included in this cohort. The cumulative mortality of underweight, normal-weight, and overweight were 2.4/100 person-years (95% CI 1.9–2.9), 1.1/100 person-years (95% CI 0.9–1.3), and 0.5/100 person-years (95% CI 0.1–0.9), respectively. Cumulative mortality was lower in both the normal-weight and overweight populations than in the underweight population, with an adjusted hazard ratio (AHR) of 0.5 (95% CI 0.4–0.7, p < 0.001) and 0.3 (95% CI 0.1–0.6, p = 0.002), respectively. Additionally, in the 1176 patients with available viral load data, there was significant difference between the underweight and normal-weight groups after adjustment for all factors, including viral load (p = 0.031). This result suggests that HIV-infected patients in Guangxi maintaining a BMI of 19–28 kg/m2, especially 24–28 kg/m2, have a reduced risk of death. |
format |
article |
author |
Junjun Jiang Xionglin Qin Huifang Liu Sirun Meng Abu S. Abdullah Jinping Huang Chunwei Qin Yanfen Liu Yunxuan Huang Fengxiang Qin Jiegang Huang Ning Zang Bingyu Liang Chuanyi Ning Yanyan Liao Hao Liang Fengyao Wu Li Ye |
author_facet |
Junjun Jiang Xionglin Qin Huifang Liu Sirun Meng Abu S. Abdullah Jinping Huang Chunwei Qin Yanfen Liu Yunxuan Huang Fengxiang Qin Jiegang Huang Ning Zang Bingyu Liang Chuanyi Ning Yanyan Liao Hao Liang Fengyao Wu Li Ye |
author_sort |
Junjun Jiang |
title |
An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
title_short |
An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
title_full |
An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
title_fullStr |
An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
title_full_unstemmed |
An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China |
title_sort |
optimal bmi range associated with a lower risk of mortality among hiv-infected adults initiating antiretroviral therapy in guangxi, china |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/5fee4f740636457d8666096c32c222f6 |
work_keys_str_mv |
AT junjunjiang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT xionglinqin anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT huifangliu anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT sirunmeng anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT abusabdullah anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT jinpinghuang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT chunweiqin anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yanfenliu anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yunxuanhuang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT fengxiangqin anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT jieganghuang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT ningzang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT bingyuliang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT chuanyining anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yanyanliao anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT haoliang anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT fengyaowu anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT liye anoptimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT junjunjiang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT xionglinqin optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT huifangliu optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT sirunmeng optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT abusabdullah optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT jinpinghuang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT chunweiqin optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yanfenliu optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yunxuanhuang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT fengxiangqin optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT jieganghuang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT ningzang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT bingyuliang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT chuanyining optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT yanyanliao optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT haoliang optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT fengyaowu optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina AT liye optimalbmirangeassociatedwithalowerriskofmortalityamonghivinfectedadultsinitiatingantiretroviraltherapyinguangxichina |
_version_ |
1718388001082441728 |