Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.

Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. In th...

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Autores principales:	Zhiyong Wang, Peixun Zhang, Yuhui Kou, Xiaofeng Yin, Na Han, Baoguo Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fee93725bde4ecc8d8210c5fe4fbfce
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spelling	oai:doaj.org-article:5fee93725bde4ecc8d8210c5fe4fbfce2021-11-18T07:38:47ZHedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.1932-620310.1371/journal.pone.0067921https://doaj.org/article/5fee93725bde4ecc8d8210c5fe4fbfce2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23844128/?tool=EBIhttps://doaj.org/toc/1932-6203Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. In this study, we explored the effect of Hedysari extract on the amplification ratio in the peripheral nerve. Male Sprague-Dawley rats were separated into three groups at random: normal group (without surgery), model group (given sleeve nerve bridging surgery, but without adjuvant treatment) and treatment group (given sleeve nerve bridging surgery and then given Hedysari extract as adjuvant treatment). Twelve weeks after surgery, general observations, electrophysiological examination, histological analysis, morphometric measurements, and amplification ratio calculations were made. The results showed that nerve conduction velocity, the fiber and axon diameter, the g-ratio, the number of regenerating nerve fibers and the amplification ratio were better in the treatment group than in the model group, suggesting that Hedysari extract can effectively promote the growth of lateral buds in the proximal nerve stump and substantially improve the amplification effect during peripheral nerve regeneration.Zhiyong WangPeixun ZhangYuhui KouXiaofeng YinNa HanBaoguo JiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e67921 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhiyong Wang Peixun Zhang Yuhui Kou Xiaofeng Yin Na Han Baoguo Jiang Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
description	Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. In this study, we explored the effect of Hedysari extract on the amplification ratio in the peripheral nerve. Male Sprague-Dawley rats were separated into three groups at random: normal group (without surgery), model group (given sleeve nerve bridging surgery, but without adjuvant treatment) and treatment group (given sleeve nerve bridging surgery and then given Hedysari extract as adjuvant treatment). Twelve weeks after surgery, general observations, electrophysiological examination, histological analysis, morphometric measurements, and amplification ratio calculations were made. The results showed that nerve conduction velocity, the fiber and axon diameter, the g-ratio, the number of regenerating nerve fibers and the amplification ratio were better in the treatment group than in the model group, suggesting that Hedysari extract can effectively promote the growth of lateral buds in the proximal nerve stump and substantially improve the amplification effect during peripheral nerve regeneration.
format	article
author	Zhiyong Wang Peixun Zhang Yuhui Kou Xiaofeng Yin Na Han Baoguo Jiang
author_facet	Zhiyong Wang Peixun Zhang Yuhui Kou Xiaofeng Yin Na Han Baoguo Jiang
author_sort	Zhiyong Wang
title	Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
title_short	Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
title_full	Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
title_fullStr	Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
title_full_unstemmed	Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
title_sort	hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5fee93725bde4ecc8d8210c5fe4fbfce
work_keys_str_mv	AT zhiyongwang hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect AT peixunzhang hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect AT yuhuikou hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect AT xiaofengyin hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect AT nahan hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect AT baoguojiang hedysariextractimprovesregenerationafterperipheralnerveinjurybyenhancingtheamplificationeffect
_version_	1718423163171241984

Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.

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