Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

During chronic infection CD4+ T cells can progressively acquire IL-10 producing functionality. Here the authors use single cell RNA sequencing to interrogate the IL10 CD4+ T cell compartment in a murine model of chronic infection and identify Il10-producing Tfh involved in promotion of the antiviral...

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Autores principales:	Gang Xin, Ryan Zander, David M. Schauder, Yao Chen, Jason S. Weinstein, William R. Drobyski, Vera Tarakanova, Joseph Craft, Weiguo Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ff106c64d614ee09a1d3854c116a13c
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spelling	oai:doaj.org-article:5ff106c64d614ee09a1d3854c116a13c2021-12-02T15:33:45ZSingle-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection10.1038/s41467-018-07492-42041-1723https://doaj.org/article/5ff106c64d614ee09a1d3854c116a13c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07492-4https://doaj.org/toc/2041-1723During chronic infection CD4+ T cells can progressively acquire IL-10 producing functionality. Here the authors use single cell RNA sequencing to interrogate the IL10 CD4+ T cell compartment in a murine model of chronic infection and identify Il10-producing Tfh involved in promotion of the antiviral humoral immune response.Gang XinRyan ZanderDavid M. SchauderYao ChenJason S. WeinsteinWilliam R. DrobyskiVera TarakanovaJoseph CraftWeiguo CuiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Xin Ryan Zander David M. Schauder Yao Chen Jason S. Weinstein William R. Drobyski Vera Tarakanova Joseph Craft Weiguo Cui Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
description	During chronic infection CD4+ T cells can progressively acquire IL-10 producing functionality. Here the authors use single cell RNA sequencing to interrogate the IL10 CD4+ T cell compartment in a murine model of chronic infection and identify Il10-producing Tfh involved in promotion of the antiviral humoral immune response.
format	article
author	Gang Xin Ryan Zander David M. Schauder Yao Chen Jason S. Weinstein William R. Drobyski Vera Tarakanova Joseph Craft Weiguo Cui
author_facet	Gang Xin Ryan Zander David M. Schauder Yao Chen Jason S. Weinstein William R. Drobyski Vera Tarakanova Joseph Craft Weiguo Cui
author_sort	Gang Xin
title	Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
title_short	Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
title_full	Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
title_fullStr	Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
title_full_unstemmed	Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection
title_sort	single-cell rna sequencing unveils an il-10-producing helper subset that sustains humoral immunity during persistent infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ff106c64d614ee09a1d3854c116a13c
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Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

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