PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment

Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the research and development (R&D) of new drugs, post-market monitoring, and continued optimizations in clinical contexts. Ultimately, pharmacokinetics can contribute to improving patients’ clinical outcomes, h...

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Autores principales:	Abigail Ferreira, Rui Lapa, Nuno Vale
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pharmacokinetics PBPK modeling and simulation therapeutic drug monitoring model-informed precision dosing antibiotic therapy Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5ff3dd9ea77c43628d8b4cda09ca76fa
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spelling	oai:doaj.org-article:5ff3dd9ea77c43628d8b4cda09ca76fa2021-11-25T18:52:15ZPBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment10.3390/pr91120872227-9717https://doaj.org/article/5ff3dd9ea77c43628d8b4cda09ca76fa2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/2087https://doaj.org/toc/2227-9717Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the research and development (R&D) of new drugs, post-market monitoring, and continued optimizations in clinical contexts. Ultimately, pharmacokinetics can contribute to improving patients’ clinical outcomes, helping enhance the efficacy of treatments, and reducing possible adverse side effects while also contributing to precision medicine. This article discusses the methods used to predict and study human pharmacokinetics and their evolution to the current physiologically based pharmacokinetic (PBPK) modeling and simulation methods. The importance of therapeutic drug monitoring (TDM) and PBPK as valuable tools for Model-Informed Precision Dosing (MIPD) are highlighted, with particular emphasis on antibiotic therapy since dosage adjustment of antibiotics can be vital to ensure successful clinical outcomes and to prevent the spread of resistant bacterial strains.Abigail FerreiraRui LapaNuno ValeMDPI AGarticlepharmacokineticsPBPK modeling and simulationtherapeutic drug monitoringmodel-informed precision dosingantibiotic therapyChemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 2087, p 2087 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pharmacokinetics PBPK modeling and simulation therapeutic drug monitoring model-informed precision dosing antibiotic therapy Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	pharmacokinetics PBPK modeling and simulation therapeutic drug monitoring model-informed precision dosing antibiotic therapy Chemical technology TP1-1185 Chemistry QD1-999 Abigail Ferreira Rui Lapa Nuno Vale PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
description	Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the research and development (R&D) of new drugs, post-market monitoring, and continued optimizations in clinical contexts. Ultimately, pharmacokinetics can contribute to improving patients’ clinical outcomes, helping enhance the efficacy of treatments, and reducing possible adverse side effects while also contributing to precision medicine. This article discusses the methods used to predict and study human pharmacokinetics and their evolution to the current physiologically based pharmacokinetic (PBPK) modeling and simulation methods. The importance of therapeutic drug monitoring (TDM) and PBPK as valuable tools for Model-Informed Precision Dosing (MIPD) are highlighted, with particular emphasis on antibiotic therapy since dosage adjustment of antibiotics can be vital to ensure successful clinical outcomes and to prevent the spread of resistant bacterial strains.
format	article
author	Abigail Ferreira Rui Lapa Nuno Vale
author_facet	Abigail Ferreira Rui Lapa Nuno Vale
author_sort	Abigail Ferreira
title	PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
title_short	PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
title_full	PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
title_fullStr	PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
title_full_unstemmed	PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment
title_sort	pbpk modeling and simulation and therapeutic drug monitoring: possible ways for antibiotic dose adjustment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5ff3dd9ea77c43628d8b4cda09ca76fa
work_keys_str_mv	AT abigailferreira pbpkmodelingandsimulationandtherapeuticdrugmonitoringpossiblewaysforantibioticdoseadjustment AT ruilapa pbpkmodelingandsimulationandtherapeuticdrugmonitoringpossiblewaysforantibioticdoseadjustment AT nunovale pbpkmodelingandsimulationandtherapeuticdrugmonitoringpossiblewaysforantibioticdoseadjustment
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PBPK Modeling and Simulation and Therapeutic Drug Monitoring: Possible Ways for Antibiotic Dose Adjustment

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