X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations

Abstract A new 16 X-short tandem repeat (STR) multiplex PCR system has recently been developed for Sr Lankans, though its applicability in evolutionary genetics and forensic investigations has not been thoroughly assessed. In this study, 838 unrelated individuals covering all four major ethnic group...

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Autores principales:	Nandika Perera, Gayani Galhena, Gaya Ranawaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ff4f63d30bc4500b77f7be675210ac8
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spelling	oai:doaj.org-article:5ff4f63d30bc4500b77f7be675210ac82021-12-02T17:24:22ZX-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations10.1038/s41598-021-92314-92045-2322https://doaj.org/article/5ff4f63d30bc4500b77f7be675210ac82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92314-9https://doaj.org/toc/2045-2322Abstract A new 16 X-short tandem repeat (STR) multiplex PCR system has recently been developed for Sr Lankans, though its applicability in evolutionary genetics and forensic investigations has not been thoroughly assessed. In this study, 838 unrelated individuals covering all four major ethnic groups (Sinhalese, Sri Lankan Tamils, Indian Tamils and Moors) in Sri Lanka were successfully genotyped using this new multiplex system. The results indicated a high forensic efficiency for the tested loci in all four ethnicities confirming its suitability for forensic applications of Sri Lankans. Allele frequency distribution of Indian Tamils showed subtle but statistically significant differences from those of Sinhalese and Moors, in contrast to frequency distributions previously reported for autosomal STR alleles. This suggest a sex biased demographic history among Sri Lankans requiring a separate X-STR allele frequency database for Indian Tamils. Substantial differences observed in the patterns of LD among the four groups demand the use of a separate haplotype frequency databases for each individual ethnicity. When analysed together with other 14 world populations, all Sri Lankan ethnicities except Indian Tamils clustered closely with populations from Indian Bhil tribe, Bangladesh and Europe reflecting their shared Indo-Aryan ancestry.Nandika PereraGayani GalhenaGaya RanawakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nandika Perera Gayani Galhena Gaya Ranawaka X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
description	Abstract A new 16 X-short tandem repeat (STR) multiplex PCR system has recently been developed for Sr Lankans, though its applicability in evolutionary genetics and forensic investigations has not been thoroughly assessed. In this study, 838 unrelated individuals covering all four major ethnic groups (Sinhalese, Sri Lankan Tamils, Indian Tamils and Moors) in Sri Lanka were successfully genotyped using this new multiplex system. The results indicated a high forensic efficiency for the tested loci in all four ethnicities confirming its suitability for forensic applications of Sri Lankans. Allele frequency distribution of Indian Tamils showed subtle but statistically significant differences from those of Sinhalese and Moors, in contrast to frequency distributions previously reported for autosomal STR alleles. This suggest a sex biased demographic history among Sri Lankans requiring a separate X-STR allele frequency database for Indian Tamils. Substantial differences observed in the patterns of LD among the four groups demand the use of a separate haplotype frequency databases for each individual ethnicity. When analysed together with other 14 world populations, all Sri Lankan ethnicities except Indian Tamils clustered closely with populations from Indian Bhil tribe, Bangladesh and Europe reflecting their shared Indo-Aryan ancestry.
format	article
author	Nandika Perera Gayani Galhena Gaya Ranawaka
author_facet	Nandika Perera Gayani Galhena Gaya Ranawaka
author_sort	Nandika Perera
title	X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
title_short	X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
title_full	X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
title_fullStr	X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
title_full_unstemmed	X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations
title_sort	x-chromosomal str based genetic polymorphisms and demographic history of sri lankan ethnicities and their relationship with global populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ff4f63d30bc4500b77f7be675210ac8
work_keys_str_mv	AT nandikaperera xchromosomalstrbasedgeneticpolymorphismsanddemographichistoryofsrilankanethnicitiesandtheirrelationshipwithglobalpopulations AT gayanigalhena xchromosomalstrbasedgeneticpolymorphismsanddemographichistoryofsrilankanethnicitiesandtheirrelationshipwithglobalpopulations AT gayaranawaka xchromosomalstrbasedgeneticpolymorphismsanddemographichistoryofsrilankanethnicitiesandtheirrelationshipwithglobalpopulations
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X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations

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