An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement

Abstract Wall Shear Stress (WSS) has been demonstrated to be a biomarker of the development of atherosclerosis. In vivo assessment of WSS is still challenging, but 4D Flow MRI represents a promising tool to provide 3D velocity data from which WSS can be calculated. In this study, a system based on L...

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Autores principales:	Marco Castagna, Sébastien Levilly, Perrine Paul-Gilloteaux, Saïd Moussaoui, Jean-Marc Rousset, Félicien Bonnefoy, Jérôme Idier, Jean-Michel Serfaty, David Le Touzé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ff5ef44a615446b9f8a4b7b55f2fcb9
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spelling	oai:doaj.org-article:5ff5ef44a615446b9f8a4b7b55f2fcb92021-12-02T14:04:39ZAn LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement10.1038/s41598-021-83633-y2045-2322https://doaj.org/article/5ff5ef44a615446b9f8a4b7b55f2fcb92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83633-yhttps://doaj.org/toc/2045-2322Abstract Wall Shear Stress (WSS) has been demonstrated to be a biomarker of the development of atherosclerosis. In vivo assessment of WSS is still challenging, but 4D Flow MRI represents a promising tool to provide 3D velocity data from which WSS can be calculated. In this study, a system based on Laser Doppler Velocimetry (LDV) was developed to validate new improvements of 4D Flow MRI acquisitions and derived WSS computing. A hydraulic circuit was manufactured to allow both 4D Flow MRI and LDV velocity measurements. WSS profiles were calculated with one 2D and one 3D method. Results indicated an excellent agreement between MRI and LDV velocity data, and thus the set-up enabled the evaluation of the improved performances of 3D with respect to the 2D-WSS computation method. To provide a concrete example of the efficacy of this method, the influence of the spatial resolution of MRI data on derived 3D-WSS profiles was investigated. This investigation showed that, with acquisition times compatible with standard clinical conditions, a refined MRI resolution does not improve WSS assessment, if the impact of noise is unreduced. This study represents a reliable basis to validate with LDV WSS calculation methods based on 4D Flow MRI.Marco CastagnaSébastien LevillyPerrine Paul-GilloteauxSaïd MoussaouiJean-Marc RoussetFélicien BonnefoyJérôme IdierJean-Michel SerfatyDavid Le TouzéNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Castagna Sébastien Levilly Perrine Paul-Gilloteaux Saïd Moussaoui Jean-Marc Rousset Félicien Bonnefoy Jérôme Idier Jean-Michel Serfaty David Le Touzé An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
description	Abstract Wall Shear Stress (WSS) has been demonstrated to be a biomarker of the development of atherosclerosis. In vivo assessment of WSS is still challenging, but 4D Flow MRI represents a promising tool to provide 3D velocity data from which WSS can be calculated. In this study, a system based on Laser Doppler Velocimetry (LDV) was developed to validate new improvements of 4D Flow MRI acquisitions and derived WSS computing. A hydraulic circuit was manufactured to allow both 4D Flow MRI and LDV velocity measurements. WSS profiles were calculated with one 2D and one 3D method. Results indicated an excellent agreement between MRI and LDV velocity data, and thus the set-up enabled the evaluation of the improved performances of 3D with respect to the 2D-WSS computation method. To provide a concrete example of the efficacy of this method, the influence of the spatial resolution of MRI data on derived 3D-WSS profiles was investigated. This investigation showed that, with acquisition times compatible with standard clinical conditions, a refined MRI resolution does not improve WSS assessment, if the impact of noise is unreduced. This study represents a reliable basis to validate with LDV WSS calculation methods based on 4D Flow MRI.
format	article
author	Marco Castagna Sébastien Levilly Perrine Paul-Gilloteaux Saïd Moussaoui Jean-Marc Rousset Félicien Bonnefoy Jérôme Idier Jean-Michel Serfaty David Le Touzé
author_facet	Marco Castagna Sébastien Levilly Perrine Paul-Gilloteaux Saïd Moussaoui Jean-Marc Rousset Félicien Bonnefoy Jérôme Idier Jean-Michel Serfaty David Le Touzé
author_sort	Marco Castagna
title	An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
title_short	An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
title_full	An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
title_fullStr	An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
title_full_unstemmed	An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement
title_sort	ldv based method to quantify the error of pc-mri derived wall shear stress measurement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ff5ef44a615446b9f8a4b7b55f2fcb9
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An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement

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