The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.

<h4>Background</h4>Warfarin-related nephropathy (WRN) is a recently described disease entity, in which excessive warfarinization (international normalized ratio (INR) >3.0) causes acute kidney injury. Previous reports regarding WRN included few Asian patients who might have differed f...

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Autores principales:	Jung Nam An, Shin Young Ahn, Chang-Hwan Yoon, Tae-Jin Youn, Moon-Ku Han, Sejoong Kim, Ho Jun Chin, Ki Young Na, Dong-Wan Chae
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ff91a41d63641589d54dd986e6edf70
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spelling	oai:doaj.org-article:5ff91a41d63641589d54dd986e6edf702021-11-18T07:51:17ZThe occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.1932-620310.1371/journal.pone.0057661https://doaj.org/article/5ff91a41d63641589d54dd986e6edf702013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23560034/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Warfarin-related nephropathy (WRN) is a recently described disease entity, in which excessive warfarinization (international normalized ratio (INR) >3.0) causes acute kidney injury. Previous reports regarding WRN included few Asian patients who might have differed from the western WRN patients in terms of genetic and environmental factors.<h4>Methods</h4>During the period of March 2003 to December 2011, the data about a total of 1297 patients who had serum creatinine (sCr) level measured within 1 week after INR >3.0 and within 6 months before INR >3.0 was analyzed through the retrospective review of electronic medical records of a single tertiary hospital in Korea.<h4>Result</h4>WRN developed in 19.3% of patients having excessive warfarinization. The incidence was higher in the chronic kidney disease (CKD) group than the non-CKD group. The risk of WRN increased as the basal serum albumin level decreased and was strongly associated with highest quartile serum AST level at post INR elevation and the presence of congestive heart failure. But the presence of atrial fibrillation was protective against the development of WRN. Neither the presence of CKD nor basal estimated glomerular filtration rate (eGFR) was an independent risk factor for WRN. Despite no difference in the basal sCr level, the sCr level was higher in patients with WRN than those without WRN after follow-up. The mortality rates were also higher in patients with WRN.<h4>Conclusions</h4>WRN developed in 19.3% of patients having excessive warfarinization. A lower basal serum albumin, highest quartile serum AST level at post INR elevation, and congestive heart failure were associated with the occurrence of WRN. The development of WRN adversely affected renal and patient outcomes.Jung Nam AnShin Young AhnChang-Hwan YoonTae-Jin YounMoon-Ku HanSejoong KimHo Jun ChinKi Young NaDong-Wan ChaePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e57661 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung Nam An Shin Young Ahn Chang-Hwan Yoon Tae-Jin Youn Moon-Ku Han Sejoong Kim Ho Jun Chin Ki Young Na Dong-Wan Chae The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
description	<h4>Background</h4>Warfarin-related nephropathy (WRN) is a recently described disease entity, in which excessive warfarinization (international normalized ratio (INR) >3.0) causes acute kidney injury. Previous reports regarding WRN included few Asian patients who might have differed from the western WRN patients in terms of genetic and environmental factors.<h4>Methods</h4>During the period of March 2003 to December 2011, the data about a total of 1297 patients who had serum creatinine (sCr) level measured within 1 week after INR >3.0 and within 6 months before INR >3.0 was analyzed through the retrospective review of electronic medical records of a single tertiary hospital in Korea.<h4>Result</h4>WRN developed in 19.3% of patients having excessive warfarinization. The incidence was higher in the chronic kidney disease (CKD) group than the non-CKD group. The risk of WRN increased as the basal serum albumin level decreased and was strongly associated with highest quartile serum AST level at post INR elevation and the presence of congestive heart failure. But the presence of atrial fibrillation was protective against the development of WRN. Neither the presence of CKD nor basal estimated glomerular filtration rate (eGFR) was an independent risk factor for WRN. Despite no difference in the basal sCr level, the sCr level was higher in patients with WRN than those without WRN after follow-up. The mortality rates were also higher in patients with WRN.<h4>Conclusions</h4>WRN developed in 19.3% of patients having excessive warfarinization. A lower basal serum albumin, highest quartile serum AST level at post INR elevation, and congestive heart failure were associated with the occurrence of WRN. The development of WRN adversely affected renal and patient outcomes.
format	article
author	Jung Nam An Shin Young Ahn Chang-Hwan Yoon Tae-Jin Youn Moon-Ku Han Sejoong Kim Ho Jun Chin Ki Young Na Dong-Wan Chae
author_facet	Jung Nam An Shin Young Ahn Chang-Hwan Yoon Tae-Jin Youn Moon-Ku Han Sejoong Kim Ho Jun Chin Ki Young Na Dong-Wan Chae
author_sort	Jung Nam An
title	The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
title_short	The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
title_full	The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
title_fullStr	The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
title_full_unstemmed	The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
title_sort	occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5ff91a41d63641589d54dd986e6edf70
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The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.

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