Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice

Background and Objective: Aluminum has been known to cause toxic effects on organ systems. Although the knowledge on Aluminum (AL) toxicity has markedly improved in recent years, information concerning the reproductive toxicity of this element is still very limited. The purpose of this study was to...

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Autores principales:	AA Karim Pour, ZH Torabi Zadeh, M Sadoughi, SS Sadeghi Darabi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2005
Materias:	aluminum chloride placental toxicity uterine toxicity teratogen Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ff91d20e4d442b993a931a2cd25d7a6
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spelling	oai:doaj.org-article:5ff91d20e4d442b993a931a2cd25d7a62021-11-10T09:14:24ZToxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice1561-41072251-7170https://doaj.org/article/5ff91d20e4d442b993a931a2cd25d7a62005-01-01T00:00:00Zhttp://jbums.org/article-1-2648-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Aluminum has been known to cause toxic effects on organ systems. Although the knowledge on Aluminum (AL) toxicity has markedly improved in recent years, information concerning the reproductive toxicity of this element is still very limited. The purpose of this study was to assess the effect of graded dose of Aluminum chloride administered to pregnant mice on their placenta and uterine in a short time. Methods: This study was performed on plug-positive female NMRI (National medical research institute) mice that were randomly divided into 6 groups (12 mice in each group). 3 groups of plug-positive female NMRI mice were given IP injections of ALCL3 at 150 mg/kg on days 10, 11 and 12 of gestation, respectively. 3 other groups were given normal saline on the same days as control groups. Mice were killed on day 15 of gestation, the weight and diameter of placenta were recorded. Both placenta and uterus were examined with stereomicroscope and also uterus fixed and stained for microscopic examination. Findings: In all experimental group, in 14.3%, 13.8% and 13.3% of fetuses, placenta showed abnormal appearance and some degrees of atrophy on days 10, 11, 12 of gestation, respectively that in comparison to control group it was significantly higher (P<0.05). Also, the diameter of placenta in experimental groups (7.2, 7.2 and 7.3 mm respectively) was significantly smaller than control groups (7.6 mm) (P<0.05). The uterine of AL treated groups showed hemorrhagic area in external examination and infiltration reaction and dispersed necrotic foci in myometer in microscopic examination. Conclusion: According to the results, ALCL3 showed toxic effect on placenta and uterus of pregnant mice. It could explain at least part of teratogenic effects of ALCL3.AA Karim PourZH Torabi ZadehM SadoughiSS Sadeghi DarabiBabol University of Medical Sciencesarticlealuminum chlorideplacental toxicityuterine toxicityteratogenMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 1, Pp 22-27 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	aluminum chloride placental toxicity uterine toxicity teratogen Medicine R Medicine (General) R5-920
spellingShingle	aluminum chloride placental toxicity uterine toxicity teratogen Medicine R Medicine (General) R5-920 AA Karim Pour ZH Torabi Zadeh M Sadoughi SS Sadeghi Darabi Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
description	Background and Objective: Aluminum has been known to cause toxic effects on organ systems. Although the knowledge on Aluminum (AL) toxicity has markedly improved in recent years, information concerning the reproductive toxicity of this element is still very limited. The purpose of this study was to assess the effect of graded dose of Aluminum chloride administered to pregnant mice on their placenta and uterine in a short time. Methods: This study was performed on plug-positive female NMRI (National medical research institute) mice that were randomly divided into 6 groups (12 mice in each group). 3 groups of plug-positive female NMRI mice were given IP injections of ALCL3 at 150 mg/kg on days 10, 11 and 12 of gestation, respectively. 3 other groups were given normal saline on the same days as control groups. Mice were killed on day 15 of gestation, the weight and diameter of placenta were recorded. Both placenta and uterus were examined with stereomicroscope and also uterus fixed and stained for microscopic examination. Findings: In all experimental group, in 14.3%, 13.8% and 13.3% of fetuses, placenta showed abnormal appearance and some degrees of atrophy on days 10, 11, 12 of gestation, respectively that in comparison to control group it was significantly higher (P<0.05). Also, the diameter of placenta in experimental groups (7.2, 7.2 and 7.3 mm respectively) was significantly smaller than control groups (7.6 mm) (P<0.05). The uterine of AL treated groups showed hemorrhagic area in external examination and infiltration reaction and dispersed necrotic foci in myometer in microscopic examination. Conclusion: According to the results, ALCL3 showed toxic effect on placenta and uterus of pregnant mice. It could explain at least part of teratogenic effects of ALCL3.
format	article
author	AA Karim Pour ZH Torabi Zadeh M Sadoughi SS Sadeghi Darabi
author_facet	AA Karim Pour ZH Torabi Zadeh M Sadoughi SS Sadeghi Darabi
author_sort	AA Karim Pour
title	Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
title_short	Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
title_full	Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
title_fullStr	Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
title_full_unstemmed	Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice
title_sort	toxicity effects of aluminum chloride on uterus and placenta of pregnant mice
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/5ff91d20e4d442b993a931a2cd25d7a6
work_keys_str_mv	AT aakarimpour toxicityeffectsofaluminumchlorideonuterusandplacentaofpregnantmice AT zhtorabizadeh toxicityeffectsofaluminumchlorideonuterusandplacentaofpregnantmice AT msadoughi toxicityeffectsofaluminumchlorideonuterusandplacentaofpregnantmice AT sssadeghidarabi toxicityeffectsofaluminumchlorideonuterusandplacentaofpregnantmice
_version_	1718440196725276672

Toxicity effects of Aluminum Chloride on uterus and placenta of pregnant mice

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