Neurological disorders and therapeutics targeted to surmount the blood–brain barrier

Jagat R Kanwar, Bhasker Sriramoju, Rupinder K KanwarNanomedicine Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences, Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, Victoria, AustraliaAbstract: We are now in...

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Autores principales: Kanwar JR, Sriramoju B, Kanwar RK
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Publicado: Dove Medical Press 2012
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spelling oai:doaj.org-article:5ffe1ee26bfe40eca32c8a61e53bef352021-12-02T02:31:37ZNeurological disorders and therapeutics targeted to surmount the blood–brain barrier1176-91141178-2013https://doaj.org/article/5ffe1ee26bfe40eca32c8a61e53bef352012-07-01T00:00:00Zhttp://www.dovepress.com/neurological-disorders-and-therapeutics-targeted-to-surmount-the-blood-a10344https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jagat R Kanwar, Bhasker Sriramoju, Rupinder K KanwarNanomedicine Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences, Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, Victoria, AustraliaAbstract: We are now in an aging population, so neurological disorders, particularly the neurodegenerative diseases, are becoming more prevalent in society. As per the epidemiological studies, Europe alone suffers 35% of the burden, indicating an alarming rate of disease progression. Further, treatment for these disorders is a challenging area due to the presence of the tightly regulated blood–brain barrier and its unique ability to protect the brain from xenobiotics. Conventional therapeutics, although effective, remain critically below levels of optimum therapeutic efficacy. Hence, methods to overcome the blood–brain barrier are currently a focus of research. Nanotechnological applications are gaining paramount importance in addressing this question, and yielding some promising results. This review addresses the pathophysiology of the more common neurological disorders and novel drug candidates, along with targeted nanoparticle applications for brain delivery.Keywords: blood–brain barrier, neurological diseases, brain delivery, targeted nanoparticlesKanwar JRSriramoju BKanwar RKDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3259-3278 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Kanwar JR
Sriramoju B
Kanwar RK
Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
description Jagat R Kanwar, Bhasker Sriramoju, Rupinder K KanwarNanomedicine Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences, Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, Victoria, AustraliaAbstract: We are now in an aging population, so neurological disorders, particularly the neurodegenerative diseases, are becoming more prevalent in society. As per the epidemiological studies, Europe alone suffers 35% of the burden, indicating an alarming rate of disease progression. Further, treatment for these disorders is a challenging area due to the presence of the tightly regulated blood–brain barrier and its unique ability to protect the brain from xenobiotics. Conventional therapeutics, although effective, remain critically below levels of optimum therapeutic efficacy. Hence, methods to overcome the blood–brain barrier are currently a focus of research. Nanotechnological applications are gaining paramount importance in addressing this question, and yielding some promising results. This review addresses the pathophysiology of the more common neurological disorders and novel drug candidates, along with targeted nanoparticle applications for brain delivery.Keywords: blood–brain barrier, neurological diseases, brain delivery, targeted nanoparticles
format article
author Kanwar JR
Sriramoju B
Kanwar RK
author_facet Kanwar JR
Sriramoju B
Kanwar RK
author_sort Kanwar JR
title Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
title_short Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
title_full Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
title_fullStr Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
title_full_unstemmed Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
title_sort neurological disorders and therapeutics targeted to surmount the blood–brain barrier
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/5ffe1ee26bfe40eca32c8a61e53bef35
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