Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.

The importance of the large number of thin-diameter and unmyelinated axons that connect different cortical areas is unknown. The pronounced propagation delays in these axons may prevent synchronization of cortical networks and therefore hinder efficient information integration and processing. Yet, s...

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Autores principales:	Katrina M Kutchko, Flavio Fröhlich
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5fff11e53359462f8ba00140746ae120
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spelling	oai:doaj.org-article:5fff11e53359462f8ba00140746ae1202021-11-18T05:53:28ZEmergence of metastable state dynamics in interconnected cortical networks with propagation delays.1553-734X1553-735810.1371/journal.pcbi.1003304https://doaj.org/article/5fff11e53359462f8ba00140746ae1202013-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204238/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The importance of the large number of thin-diameter and unmyelinated axons that connect different cortical areas is unknown. The pronounced propagation delays in these axons may prevent synchronization of cortical networks and therefore hinder efficient information integration and processing. Yet, such global information integration across cortical areas is vital for higher cognitive function. We hypothesized that delays in communication between cortical areas can disrupt synchronization and therefore enhance the set of activity trajectories and computations interconnected networks can perform. To evaluate this hypothesis, we studied the effect of long-range cortical projections with propagation delays in interconnected large-scale cortical networks that exhibited spontaneous rhythmic activity. Long-range connections with delays caused the emergence of metastable, spatio-temporally distinct activity states between which the networks spontaneously transitioned. Interestingly, the observed activity patterns correspond to macroscopic network dynamics such as globally synchronized activity, propagating wave fronts, and spiral waves that have been previously observed in neurophysiological recordings from humans and animal models. Transient perturbations with simulated transcranial alternating current stimulation (tACS) confirmed the multistability of the interconnected networks by switching the networks between these metastable states. Our model thus proposes that slower long-range connections enrich the landscape of activity states and represent a parsimonious mechanism for the emergence of multistability in cortical networks. These results further provide a mechanistic link between the known deficits in connectivity and cortical state dynamics in neuropsychiatric illnesses such as schizophrenia and autism, as well as suggest non-invasive brain stimulation as an effective treatment for these illnesses.Katrina M KutchkoFlavio FröhlichPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 10, p e1003304 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Katrina M Kutchko Flavio Fröhlich Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
description	The importance of the large number of thin-diameter and unmyelinated axons that connect different cortical areas is unknown. The pronounced propagation delays in these axons may prevent synchronization of cortical networks and therefore hinder efficient information integration and processing. Yet, such global information integration across cortical areas is vital for higher cognitive function. We hypothesized that delays in communication between cortical areas can disrupt synchronization and therefore enhance the set of activity trajectories and computations interconnected networks can perform. To evaluate this hypothesis, we studied the effect of long-range cortical projections with propagation delays in interconnected large-scale cortical networks that exhibited spontaneous rhythmic activity. Long-range connections with delays caused the emergence of metastable, spatio-temporally distinct activity states between which the networks spontaneously transitioned. Interestingly, the observed activity patterns correspond to macroscopic network dynamics such as globally synchronized activity, propagating wave fronts, and spiral waves that have been previously observed in neurophysiological recordings from humans and animal models. Transient perturbations with simulated transcranial alternating current stimulation (tACS) confirmed the multistability of the interconnected networks by switching the networks between these metastable states. Our model thus proposes that slower long-range connections enrich the landscape of activity states and represent a parsimonious mechanism for the emergence of multistability in cortical networks. These results further provide a mechanistic link between the known deficits in connectivity and cortical state dynamics in neuropsychiatric illnesses such as schizophrenia and autism, as well as suggest non-invasive brain stimulation as an effective treatment for these illnesses.
format	article
author	Katrina M Kutchko Flavio Fröhlich
author_facet	Katrina M Kutchko Flavio Fröhlich
author_sort	Katrina M Kutchko
title	Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
title_short	Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
title_full	Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
title_fullStr	Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
title_full_unstemmed	Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
title_sort	emergence of metastable state dynamics in interconnected cortical networks with propagation delays.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5fff11e53359462f8ba00140746ae120
work_keys_str_mv	AT katrinamkutchko emergenceofmetastablestatedynamicsininterconnectedcorticalnetworkswithpropagationdelays AT flaviofrohlich emergenceofmetastablestatedynamicsininterconnectedcorticalnetworkswithpropagationdelays
_version_	1718424669324836864

Emergence of metastable state dynamics in interconnected cortical networks with propagation delays.

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