Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics

The impact of respiratory coinfections in COVID-19 is still not well understood despite the growing evidence that consider coinfections greater than expected. A total of 295 patients older than 18 years of age, hospitalized with a confirmed diagnosis of moderate/severe pneumonia due to SARS-CoV-2 in...

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Autores principales:	Giancarlo Pérez-Lazo, Wilmer Silva-Caso, Juana del Valle-Mendoza, Adriana Morales-Moreno, José Ballena-López, Fernando Soto-Febres, Johanna Martins-Luna, Hugo Carrillo-Ng, Luís J. del Valle, Sungmin Kym, Miguel Angel Aguilar-Luis, Issac Peña-Tuesta, Carmen Tinco-Valdez, Luis Ricardo Illescas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coinfections COVID-19 antibiotics Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6001f795b10149c4a9eecb445d48cdd3
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spelling	oai:doaj.org-article:6001f795b10149c4a9eecb445d48cdd32021-11-25T16:23:32ZIdentification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics10.3390/antibiotics101113582079-6382https://doaj.org/article/6001f795b10149c4a9eecb445d48cdd32021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1358https://doaj.org/toc/2079-6382The impact of respiratory coinfections in COVID-19 is still not well understood despite the growing evidence that consider coinfections greater than expected. A total of 295 patients older than 18 years of age, hospitalized with a confirmed diagnosis of moderate/severe pneumonia due to SARS-CoV-2 infection (according to definitions established by the Ministry of Health of Peru) were enrolled during the study period. A coinfection with one or more respiratory pathogens was detected in 154 (52.2%) patients at hospital admission. The most common coinfections were <i>Mycoplasma pneumoniae</i> (28.1%), <i>Chlamydia pneumoniae</i> (8.8%) and with both bacteria (11.5%); followed by Adenovirus (1.7%), <i>Mycoplasma pneumoniae</i>/Adenovirus (0.7%), <i>Chlamydia pneumoniae</i>/Adenovirus (0.7%), RSV-B/<i>Chlamydia pneumoniae</i> (0.3%) and <i>Mycoplasma pneumoniae</i>/<i>Chlamydia pneumoniae</i>/Adenovirus (0.3%). Expectoration was less frequent in coinfected individuals compared to non-coinfected (5.8% vs. 12.8%). Sepsis was more frequent among coinfected patients than non-coinfected individuals (33.1% vs. 20.6%) and 41% of the patients who received macrolides empirically were PCR-positive for <i>Mycoplasma pneumoniae</i> and <i>Chlamydia pneumoniae</i>.Giancarlo Pérez-LazoWilmer Silva-CasoJuana del Valle-MendozaAdriana Morales-MorenoJosé Ballena-LópezFernando Soto-FebresJohanna Martins-LunaHugo Carrillo-NgLuís J. del ValleSungmin KymMiguel Angel Aguilar-LuisIssac Peña-TuestaCarmen Tinco-ValdezLuis Ricardo IllescasMDPI AGarticlecoinfectionsCOVID-19antibioticsTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1358, p 1358 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coinfections COVID-19 antibiotics Therapeutics. Pharmacology RM1-950
spellingShingle	coinfections COVID-19 antibiotics Therapeutics. Pharmacology RM1-950 Giancarlo Pérez-Lazo Wilmer Silva-Caso Juana del Valle-Mendoza Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Hugo Carrillo-Ng Luís J. del Valle Sungmin Kym Miguel Angel Aguilar-Luis Issac Peña-Tuesta Carmen Tinco-Valdez Luis Ricardo Illescas Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
description	The impact of respiratory coinfections in COVID-19 is still not well understood despite the growing evidence that consider coinfections greater than expected. A total of 295 patients older than 18 years of age, hospitalized with a confirmed diagnosis of moderate/severe pneumonia due to SARS-CoV-2 infection (according to definitions established by the Ministry of Health of Peru) were enrolled during the study period. A coinfection with one or more respiratory pathogens was detected in 154 (52.2%) patients at hospital admission. The most common coinfections were <i>Mycoplasma pneumoniae</i> (28.1%), <i>Chlamydia pneumoniae</i> (8.8%) and with both bacteria (11.5%); followed by Adenovirus (1.7%), <i>Mycoplasma pneumoniae</i>/Adenovirus (0.7%), <i>Chlamydia pneumoniae</i>/Adenovirus (0.7%), RSV-B/<i>Chlamydia pneumoniae</i> (0.3%) and <i>Mycoplasma pneumoniae</i>/<i>Chlamydia pneumoniae</i>/Adenovirus (0.3%). Expectoration was less frequent in coinfected individuals compared to non-coinfected (5.8% vs. 12.8%). Sepsis was more frequent among coinfected patients than non-coinfected individuals (33.1% vs. 20.6%) and 41% of the patients who received macrolides empirically were PCR-positive for <i>Mycoplasma pneumoniae</i> and <i>Chlamydia pneumoniae</i>.
format	article
author	Giancarlo Pérez-Lazo Wilmer Silva-Caso Juana del Valle-Mendoza Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Hugo Carrillo-Ng Luís J. del Valle Sungmin Kym Miguel Angel Aguilar-Luis Issac Peña-Tuesta Carmen Tinco-Valdez Luis Ricardo Illescas
author_facet	Giancarlo Pérez-Lazo Wilmer Silva-Caso Juana del Valle-Mendoza Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Hugo Carrillo-Ng Luís J. del Valle Sungmin Kym Miguel Angel Aguilar-Luis Issac Peña-Tuesta Carmen Tinco-Valdez Luis Ricardo Illescas
author_sort	Giancarlo Pérez-Lazo
title	Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
title_short	Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
title_full	Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
title_fullStr	Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
title_full_unstemmed	Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics
title_sort	identification of coinfections by viral and bacterial pathogens in covid-19 hospitalized patients in peru: molecular diagnosis and clinical characteristics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6001f795b10149c4a9eecb445d48cdd3
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Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics

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