Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL.
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Nature Portfolio
2021
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oai:doaj.org-article:6005c21ca6e84b989b1eb0469795a79b2021-12-02T15:15:14ZSuper-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma10.1038/s41467-021-25379-92041-1723https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25379-9https://doaj.org/toc/2041-1723Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL.Huan-Chang LiangMariantonia CostanzaNicole PrutschMark W. ZimmermanElisabeth GurnhoferIvonne A. Montes-MojarroBrian J. AbrahamNina ProkophStefan StoiberSimone TangermannCosimo LobelloJan OppeltIoannis AnagnostopoulosThomas HielscherShahid PervezWolfram KlapperFrancesca ZammarchiDaniel-Adriano SilvaK. Christopher GarciaDavid BakerMartin JanzNikolai SchleussnerFalko FendŠárka PospíšilováAndrea JanikováJacqueline WallwitzDagmar StoiberIngrid Simonitsch-KluppLorenzo CerroniStefano PileriLaurence de LevalDavid SibonVirginie FataccioliPhilippe GaulardChalid AssafFabian KnörrChristine Damm-WelkWilhelm WoessmannSuzanne D. TurnerA. Thomas LookStephan MathasLukas KennerOlaf MerkelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Huan-Chang Liang Mariantonia Costanza Nicole Prutsch Mark W. Zimmerman Elisabeth Gurnhofer Ivonne A. Montes-Mojarro Brian J. Abraham Nina Prokoph Stefan Stoiber Simone Tangermann Cosimo Lobello Jan Oppelt Ioannis Anagnostopoulos Thomas Hielscher Shahid Pervez Wolfram Klapper Francesca Zammarchi Daniel-Adriano Silva K. Christopher Garcia David Baker Martin Janz Nikolai Schleussner Falko Fend Šárka Pospíšilová Andrea Janiková Jacqueline Wallwitz Dagmar Stoiber Ingrid Simonitsch-Klupp Lorenzo Cerroni Stefano Pileri Laurence de Leval David Sibon Virginie Fataccioli Philippe Gaulard Chalid Assaf Fabian Knörr Christine Damm-Welk Wilhelm Woessmann Suzanne D. Turner A. Thomas Look Stephan Mathas Lukas Kenner Olaf Merkel Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| description |
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL. |
| format |
article |
| author |
Huan-Chang Liang Mariantonia Costanza Nicole Prutsch Mark W. Zimmerman Elisabeth Gurnhofer Ivonne A. Montes-Mojarro Brian J. Abraham Nina Prokoph Stefan Stoiber Simone Tangermann Cosimo Lobello Jan Oppelt Ioannis Anagnostopoulos Thomas Hielscher Shahid Pervez Wolfram Klapper Francesca Zammarchi Daniel-Adriano Silva K. Christopher Garcia David Baker Martin Janz Nikolai Schleussner Falko Fend Šárka Pospíšilová Andrea Janiková Jacqueline Wallwitz Dagmar Stoiber Ingrid Simonitsch-Klupp Lorenzo Cerroni Stefano Pileri Laurence de Leval David Sibon Virginie Fataccioli Philippe Gaulard Chalid Assaf Fabian Knörr Christine Damm-Welk Wilhelm Woessmann Suzanne D. Turner A. Thomas Look Stephan Mathas Lukas Kenner Olaf Merkel |
| author_facet |
Huan-Chang Liang Mariantonia Costanza Nicole Prutsch Mark W. Zimmerman Elisabeth Gurnhofer Ivonne A. Montes-Mojarro Brian J. Abraham Nina Prokoph Stefan Stoiber Simone Tangermann Cosimo Lobello Jan Oppelt Ioannis Anagnostopoulos Thomas Hielscher Shahid Pervez Wolfram Klapper Francesca Zammarchi Daniel-Adriano Silva K. Christopher Garcia David Baker Martin Janz Nikolai Schleussner Falko Fend Šárka Pospíšilová Andrea Janiková Jacqueline Wallwitz Dagmar Stoiber Ingrid Simonitsch-Klupp Lorenzo Cerroni Stefano Pileri Laurence de Leval David Sibon Virginie Fataccioli Philippe Gaulard Chalid Assaf Fabian Knörr Christine Damm-Welk Wilhelm Woessmann Suzanne D. Turner A. Thomas Look Stephan Mathas Lukas Kenner Olaf Merkel |
| author_sort |
Huan-Chang Liang |
| title |
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| title_short |
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| title_full |
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| title_fullStr |
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| title_full_unstemmed |
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma |
| title_sort |
super-enhancer-based identification of a batf3/il-2r−module reveals vulnerabilities in anaplastic large cell lymphoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b |
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