Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis

Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 patients with chronic hepatitis B (CHB) and fr...

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Autores principales:	Ling Tong, Cuilin Yan, Minjie Wang, Jiajia Yang, Hongmei Wang, Ying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adenosylhomocysteinase (AHCY) exosomes hepatitis B-related cirrhosis (HBV-LC) prognosis predictor chronic hepatitis B (CHB) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6005c80f63b043b3a90ed1978091ac0c
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spelling	oai:doaj.org-article:6005c80f63b043b3a90ed1978091ac0c2021-11-08T06:21:17ZPrognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis2296-858X10.3389/fmed.2021.777452https://doaj.org/article/6005c80f63b043b3a90ed1978091ac0c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.777452/fullhttps://doaj.org/toc/2296-858XObjective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 patients with chronic hepatitis B (CHB) and from 114 HBV-LC patients to test serum exosomal AHCY expression using ELISA.Results: Compared with the CHB and Grade A and B HBV-LC groups, the level of exosomal AHCY expression was significantly higher in the HBV-LC group [376.62 (291.50–448.02) vs. 248.12 (189.28–324.63), P > 0.001] and the Grade C HBV-LC group [408.70 (365.63–465.76) vs. 279.76 (215.16–336.07), P > 0.001], respectively. Serum exosomal AHCY expression and MELD score had a significant positive correlation (r = 0.844, P < 0.001). Survival curve analysis showed that patients with low exosomal AHCY expression had significantly longer survival than patients with high exosomal AHCY expression (P = 0.0038). The receiver operating characteristics (ROC) curve showed that the area under the curve (AUC) value for the mortality prediction ability of serum exosomal AHCY in HBV-LC patients was 0.921, which was higher than the values for the MELD score (AUC 0.815) and Child-Pugh classification (AUC 0.832), with a sensitivity and specificity of 93.41 and 76.00%, respectively.Conclusions: The serum exosomal AHCY level is a novel potential prognostic biomarker in HBV-LC patients, which may be great significance for the prognosis of HBV-LC patients.Ling TongCuilin YanMinjie WangJiajia YangHongmei WangYing WangFrontiers Media S.A.articleadenosylhomocysteinase (AHCY)exosomeshepatitis B-related cirrhosis (HBV-LC)prognosis predictorchronic hepatitis B (CHB)Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenosylhomocysteinase (AHCY) exosomes hepatitis B-related cirrhosis (HBV-LC) prognosis predictor chronic hepatitis B (CHB) Medicine (General) R5-920
spellingShingle	adenosylhomocysteinase (AHCY) exosomes hepatitis B-related cirrhosis (HBV-LC) prognosis predictor chronic hepatitis B (CHB) Medicine (General) R5-920 Ling Tong Cuilin Yan Minjie Wang Jiajia Yang Hongmei Wang Ying Wang Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
description	Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 patients with chronic hepatitis B (CHB) and from 114 HBV-LC patients to test serum exosomal AHCY expression using ELISA.Results: Compared with the CHB and Grade A and B HBV-LC groups, the level of exosomal AHCY expression was significantly higher in the HBV-LC group [376.62 (291.50–448.02) vs. 248.12 (189.28–324.63), P > 0.001] and the Grade C HBV-LC group [408.70 (365.63–465.76) vs. 279.76 (215.16–336.07), P > 0.001], respectively. Serum exosomal AHCY expression and MELD score had a significant positive correlation (r = 0.844, P < 0.001). Survival curve analysis showed that patients with low exosomal AHCY expression had significantly longer survival than patients with high exosomal AHCY expression (P = 0.0038). The receiver operating characteristics (ROC) curve showed that the area under the curve (AUC) value for the mortality prediction ability of serum exosomal AHCY in HBV-LC patients was 0.921, which was higher than the values for the MELD score (AUC 0.815) and Child-Pugh classification (AUC 0.832), with a sensitivity and specificity of 93.41 and 76.00%, respectively.Conclusions: The serum exosomal AHCY level is a novel potential prognostic biomarker in HBV-LC patients, which may be great significance for the prognosis of HBV-LC patients.
format	article
author	Ling Tong Cuilin Yan Minjie Wang Jiajia Yang Hongmei Wang Ying Wang
author_facet	Ling Tong Cuilin Yan Minjie Wang Jiajia Yang Hongmei Wang Ying Wang
author_sort	Ling Tong
title	Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
title_short	Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
title_full	Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
title_fullStr	Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
title_full_unstemmed	Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
title_sort	prognostic value of serum exosomal ahcy expression in hepatitis b-induced liver cirrhosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6005c80f63b043b3a90ed1978091ac0c
work_keys_str_mv	AT lingtong prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis AT cuilinyan prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis AT minjiewang prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis AT jiajiayang prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis AT hongmeiwang prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis AT yingwang prognosticvalueofserumexosomalahcyexpressioninhepatitisbinducedlivercirrhosis
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Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis

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