Engineering regulatory networks for complex phenotypes in E. coli

Regulatory networks respond to environmental and genetic perturbations by reprogramming metabolism. Here the authors screen a library of 82 regulators with 110,120 mutations to map the regulatory network of 4000 genes.

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Detalles Bibliográficos
Autores principales:	Rongming Liu, Liya Liang, Emily F. Freed, Alaksh Choudhury, Carrie A. Eckert, Ryan T. Gill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/600753d8182544abaa6cc9ffdf23ce81
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id	oai:doaj.org-article:600753d8182544abaa6cc9ffdf23ce81
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spelling	oai:doaj.org-article:600753d8182544abaa6cc9ffdf23ce812021-12-02T16:43:39ZEngineering regulatory networks for complex phenotypes in E. coli10.1038/s41467-020-17721-42041-1723https://doaj.org/article/600753d8182544abaa6cc9ffdf23ce812020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17721-4https://doaj.org/toc/2041-1723Regulatory networks respond to environmental and genetic perturbations by reprogramming metabolism. Here the authors screen a library of 82 regulators with 110,120 mutations to map the regulatory network of 4000 genes.Rongming LiuLiya LiangEmily F. FreedAlaksh ChoudhuryCarrie A. EckertRyan T. GillNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rongming Liu Liya Liang Emily F. Freed Alaksh Choudhury Carrie A. Eckert Ryan T. Gill Engineering regulatory networks for complex phenotypes in E. coli
description	Regulatory networks respond to environmental and genetic perturbations by reprogramming metabolism. Here the authors screen a library of 82 regulators with 110,120 mutations to map the regulatory network of 4000 genes.
format	article
author	Rongming Liu Liya Liang Emily F. Freed Alaksh Choudhury Carrie A. Eckert Ryan T. Gill
author_facet	Rongming Liu Liya Liang Emily F. Freed Alaksh Choudhury Carrie A. Eckert Ryan T. Gill
author_sort	Rongming Liu
title	Engineering regulatory networks for complex phenotypes in E. coli
title_short	Engineering regulatory networks for complex phenotypes in E. coli
title_full	Engineering regulatory networks for complex phenotypes in E. coli
title_fullStr	Engineering regulatory networks for complex phenotypes in E. coli
title_full_unstemmed	Engineering regulatory networks for complex phenotypes in E. coli
title_sort	engineering regulatory networks for complex phenotypes in e. coli
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/600753d8182544abaa6cc9ffdf23ce81
work_keys_str_mv	AT rongmingliu engineeringregulatorynetworksforcomplexphenotypesinecoli AT liyaliang engineeringregulatorynetworksforcomplexphenotypesinecoli AT emilyffreed engineeringregulatorynetworksforcomplexphenotypesinecoli AT alakshchoudhury engineeringregulatorynetworksforcomplexphenotypesinecoli AT carrieaeckert engineeringregulatorynetworksforcomplexphenotypesinecoli AT ryantgill engineeringregulatorynetworksforcomplexphenotypesinecoli
_version_	1718383518828986368

Engineering regulatory networks for complex phenotypes in E. coli

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