Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats

Abstract Background Previous studies have revealed that ventrolateral orbital cortex (VLO) may play an important role in the regulation of emotional behavior. However, it is not known what effect VLO damage will have on emotion regulation. Results Data showed that damage of VLO increased the anxiety...

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Autores principales:	Zheng Chu, Wei Han, Peng Liu, Fei Liu, Gang Lei, Lisha Deng, Liu Yang, Yonghui Dang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ventrolateral orbital cortex Depression Anxiety Aggression Chronic unpredicted mild stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/600ad76e4cc7400fb284d7f109f63f84
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spelling	oai:doaj.org-article:600ad76e4cc7400fb284d7f109f63f842021-11-28T12:30:36ZElectrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats10.1186/s12868-021-00677-61471-2202https://doaj.org/article/600ad76e4cc7400fb284d7f109f63f842021-11-01T00:00:00Zhttps://doi.org/10.1186/s12868-021-00677-6https://doaj.org/toc/1471-2202Abstract Background Previous studies have revealed that ventrolateral orbital cortex (VLO) may play an important role in the regulation of emotional behavior. However, it is not known what effect VLO damage will have on emotion regulation. Results Data showed that damage of VLO increased the anxiety-like behavior in open field test and elevated plus maze, and decreased the depressive behavior in forced swimming test and learned helplessness test. Besides, the impulsive aggressive behaviors were also increased while the attack latency decreased after VLO lesion. What’s more, damage of VLO decreased depressive behaviors induced by chronic unpredicted mild stress in rats. Conclusions These results suggest that the integrity of VLO plays an important role in emotional regulation, and the damage of VLO may inhibit the development of depression-like behavior.Zheng ChuWei HanPeng LiuFei LiuGang LeiLisha DengLiu YangYonghui DangBMCarticleVentrolateral orbital cortexDepressionAnxietyAggressionChronic unpredicted mild stressNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENBMC Neuroscience, Vol 22, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ventrolateral orbital cortex Depression Anxiety Aggression Chronic unpredicted mild stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Ventrolateral orbital cortex Depression Anxiety Aggression Chronic unpredicted mild stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Zheng Chu Wei Han Peng Liu Fei Liu Gang Lei Lisha Deng Liu Yang Yonghui Dang Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
description	Abstract Background Previous studies have revealed that ventrolateral orbital cortex (VLO) may play an important role in the regulation of emotional behavior. However, it is not known what effect VLO damage will have on emotion regulation. Results Data showed that damage of VLO increased the anxiety-like behavior in open field test and elevated plus maze, and decreased the depressive behavior in forced swimming test and learned helplessness test. Besides, the impulsive aggressive behaviors were also increased while the attack latency decreased after VLO lesion. What’s more, damage of VLO decreased depressive behaviors induced by chronic unpredicted mild stress in rats. Conclusions These results suggest that the integrity of VLO plays an important role in emotional regulation, and the damage of VLO may inhibit the development of depression-like behavior.
format	article
author	Zheng Chu Wei Han Peng Liu Fei Liu Gang Lei Lisha Deng Liu Yang Yonghui Dang
author_facet	Zheng Chu Wei Han Peng Liu Fei Liu Gang Lei Lisha Deng Liu Yang Yonghui Dang
author_sort	Zheng Chu
title	Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
title_short	Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
title_full	Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
title_fullStr	Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
title_full_unstemmed	Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
title_sort	electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
publisher	BMC
publishDate	2021
url	https://doaj.org/article/600ad76e4cc7400fb284d7f109f63f84
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Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats

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