Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients

Aim: This study aimed to investigate the clinicopathological features and prognosis of immunoglobulin A nephropathy (IgAN) with arterial-arteriolar sclerosis (AS).Methods: Patients with biopsy-proven IgAN from the West China Hospital of Sichuan University were retrospectively enrolled. Clinicopathol...

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Autores principales:	Lingqiu Dong, Jiaxing Tan, Fangming Li, Siqing Wang, Zheng Jiang, Aiya Qin, Zhengxia Zhong, Xiaoyuan Zhou, Yi Tang, Wei Qin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IgA nephropathy end-stage renal disease renal survival chronic kidney disease arterial-arteriolar sclerosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/600af606df2e4d06a705cf5dc1382988
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spelling	oai:doaj.org-article:600af606df2e4d06a705cf5dc13829882021-11-17T05:35:05ZArterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients2296-858X10.3389/fmed.2021.761897https://doaj.org/article/600af606df2e4d06a705cf5dc13829882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.761897/fullhttps://doaj.org/toc/2296-858XAim: This study aimed to investigate the clinicopathological features and prognosis of immunoglobulin A nephropathy (IgAN) with arterial-arteriolar sclerosis (AS).Methods: Patients with biopsy-proven IgAN from the West China Hospital of Sichuan University were retrospectively enrolled. Clinicopathological features were collected. Patients were categorized based on the presence and the severity of the AS. All the patients were regularly followed-up until a composite end point. The correlation between AS and prognosis of IgAN was assessed.Results: A total of 1,424 patients were recruited and followed for 60.0 ± 28.7 months. Patients with AS tended to have older age, higher blood pressure, heavier proteinuria, higher serum creatinine, uric acid, and total triglyceride (TG). Meanwhile, they were more likely to have a lower estimated glomerular filtration rate (eGFR), hemoglobin, and albumin. At the end of follow-up, 126 patients in the AS group and 47 patients in the non-AS group had reached the composite end point (p < 0.001). AS was associated with the renal outcome (log-rank p < 0.001) and was an independent risk factor for the progression of IgAN (p = 0.049). The severity of AS was associated with renal outcomes (log-rank p < 0.001) and there was a trend that it might serve as an independent risk marker for progression of IgAN. In the subgroup analysis, patients presenting with AS and lower eGFR, albumin, and hemoglobin or higher proteinuria, uric acid, and TG had a significant trend for a shorter time to reach the end point (log-rank p < 0.001).Conclusion: AS was commonly seen in patients with IgAN and was independently associated with the poor prognosis.Lingqiu DongLingqiu DongJiaxing TanJiaxing TanFangming LiFangming LiSiqing WangSiqing WangZheng JiangZheng JiangAiya QinAiya QinZhengxia ZhongXiaoyuan ZhouYi TangWei QinFrontiers Media S.A.articleIgA nephropathyend-stage renal diseaserenal survivalchronic kidney diseasearterial-arteriolar sclerosisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IgA nephropathy end-stage renal disease renal survival chronic kidney disease arterial-arteriolar sclerosis Medicine (General) R5-920
spellingShingle	IgA nephropathy end-stage renal disease renal survival chronic kidney disease arterial-arteriolar sclerosis Medicine (General) R5-920 Lingqiu Dong Lingqiu Dong Jiaxing Tan Jiaxing Tan Fangming Li Fangming Li Siqing Wang Siqing Wang Zheng Jiang Zheng Jiang Aiya Qin Aiya Qin Zhengxia Zhong Xiaoyuan Zhou Yi Tang Wei Qin Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
description	Aim: This study aimed to investigate the clinicopathological features and prognosis of immunoglobulin A nephropathy (IgAN) with arterial-arteriolar sclerosis (AS).Methods: Patients with biopsy-proven IgAN from the West China Hospital of Sichuan University were retrospectively enrolled. Clinicopathological features were collected. Patients were categorized based on the presence and the severity of the AS. All the patients were regularly followed-up until a composite end point. The correlation between AS and prognosis of IgAN was assessed.Results: A total of 1,424 patients were recruited and followed for 60.0 ± 28.7 months. Patients with AS tended to have older age, higher blood pressure, heavier proteinuria, higher serum creatinine, uric acid, and total triglyceride (TG). Meanwhile, they were more likely to have a lower estimated glomerular filtration rate (eGFR), hemoglobin, and albumin. At the end of follow-up, 126 patients in the AS group and 47 patients in the non-AS group had reached the composite end point (p < 0.001). AS was associated with the renal outcome (log-rank p < 0.001) and was an independent risk factor for the progression of IgAN (p = 0.049). The severity of AS was associated with renal outcomes (log-rank p < 0.001) and there was a trend that it might serve as an independent risk marker for progression of IgAN. In the subgroup analysis, patients presenting with AS and lower eGFR, albumin, and hemoglobin or higher proteinuria, uric acid, and TG had a significant trend for a shorter time to reach the end point (log-rank p < 0.001).Conclusion: AS was commonly seen in patients with IgAN and was independently associated with the poor prognosis.
format	article
author	Lingqiu Dong Lingqiu Dong Jiaxing Tan Jiaxing Tan Fangming Li Fangming Li Siqing Wang Siqing Wang Zheng Jiang Zheng Jiang Aiya Qin Aiya Qin Zhengxia Zhong Xiaoyuan Zhou Yi Tang Wei Qin
author_facet	Lingqiu Dong Lingqiu Dong Jiaxing Tan Jiaxing Tan Fangming Li Fangming Li Siqing Wang Siqing Wang Zheng Jiang Zheng Jiang Aiya Qin Aiya Qin Zhengxia Zhong Xiaoyuan Zhou Yi Tang Wei Qin
author_sort	Lingqiu Dong
title	Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
title_short	Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
title_full	Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
title_fullStr	Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
title_full_unstemmed	Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients
title_sort	arterial-arteriolar sclerosis is independently associated with poor renal outcome in iga nephropathy patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/600af606df2e4d06a705cf5dc1382988
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Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients

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