Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study

Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study

Andrew M Williams,1 Wei Huang,2 Kelly W Muir,3,4 Sandra S Stinnett,3 Jordan S Stone,5 Jullia A Rosdahl3 1Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Charlotte Eye Ear Nose & Throat Associates, Charlotte, NC, USA; 3Department of Ophthalmology,...

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Autores principales: Williams AM, Huang W, Muir KW, Stinnett SS, Stone JS, Rosdahl JA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
glaucoma
blindness
POAG
race
disparity
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/600e53833f254ac99093a5020dcc3f93
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spelling oai:doaj.org-article:600e53833f254ac99093a5020dcc3f932021-12-02T05:45:10ZIdentifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study1177-5483https://doaj.org/article/600e53833f254ac99093a5020dcc3f932018-02-01T00:00:00Zhttps://www.dovepress.com/identifying-risk-factors-for-blindness-from-primary-open-angle-glaucom-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Andrew M Williams,1 Wei Huang,2 Kelly W Muir,3,4 Sandra S Stinnett,3 Jordan S Stone,5 Jullia A Rosdahl3 1Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Charlotte Eye Ear Nose & Throat Associates, Charlotte, NC, USA; 3Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA; 4Health Services Research and Development, Durham Veterans Affairs Medical Center, Durham, NC, USA; 5School of Medicine, University of California San Diego, La Jolla, CA, USA Purpose: To examine the factors associated with blindness from primary open-angle glaucoma (POAG) among black and white patients at our institution.Patients and methods: For this retrospective, case–control study, patients legally blind from POAG (“cases”) were matched on age, race, and gender with non-blind POAG patients (“controls”). Thirty-seven black case–control pairs and 19 white case–control pairs were included in this study. Clinical variables were compared at initial presentation and over the course of follow-up.Results: Black case–control pairs and white case–control pairs had similar characteristics at presentation, including cup-to-disc ratio and number of glaucoma medications. However, over the course of follow-up, black cases underwent significantly more glaucoma surgeries than matched controls (2.4 versus 1.2, p=0.001), whereas white cases and controls had no significant difference in glaucoma operations (0.9 versus 0.6, p=0.139). Our analysis found that glaucoma surgery is associated with blindness in black patients (odds ratio [OR] 1.6, 95% CI 1.1–2.2) but not in white patients (OR 1.5, 95% CI 0.7–3.2).Conclusion: Black and white case–control pairs with POAG shared similar risk factors for blindness at presentation. However, over the follow-up period, black cases required significantly more glaucoma surgeries compared to black controls, whereas there was no significant difference in surgery between white cases and controls. There was no difference in medication changes in either case–control set. Keywords: health disparities, glaucoma surgery, glaucoma treatment, glaucoma medications Williams AMHuang WMuir KWStinnett SSStone JSRosdahl JADove Medical PressarticleglaucomablindnessPOAGracedisparityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 377-383 (2018)
institution DOAJ
collection DOAJ
language EN
topic glaucoma
blindness
POAG
race
disparity
Ophthalmology
RE1-994
spellingShingle glaucoma
blindness
POAG
race
disparity
Ophthalmology
RE1-994
Williams AM
Huang W
Muir KW
Stinnett SS
Stone JS
Rosdahl JA
Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
description Andrew M Williams,1 Wei Huang,2 Kelly W Muir,3,4 Sandra S Stinnett,3 Jordan S Stone,5 Jullia A Rosdahl3 1Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Charlotte Eye Ear Nose & Throat Associates, Charlotte, NC, USA; 3Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA; 4Health Services Research and Development, Durham Veterans Affairs Medical Center, Durham, NC, USA; 5School of Medicine, University of California San Diego, La Jolla, CA, USA Purpose: To examine the factors associated with blindness from primary open-angle glaucoma (POAG) among black and white patients at our institution.Patients and methods: For this retrospective, case–control study, patients legally blind from POAG (“cases”) were matched on age, race, and gender with non-blind POAG patients (“controls”). Thirty-seven black case–control pairs and 19 white case–control pairs were included in this study. Clinical variables were compared at initial presentation and over the course of follow-up.Results: Black case–control pairs and white case–control pairs had similar characteristics at presentation, including cup-to-disc ratio and number of glaucoma medications. However, over the course of follow-up, black cases underwent significantly more glaucoma surgeries than matched controls (2.4 versus 1.2, p=0.001), whereas white cases and controls had no significant difference in glaucoma operations (0.9 versus 0.6, p=0.139). Our analysis found that glaucoma surgery is associated with blindness in black patients (odds ratio [OR] 1.6, 95% CI 1.1–2.2) but not in white patients (OR 1.5, 95% CI 0.7–3.2).Conclusion: Black and white case–control pairs with POAG shared similar risk factors for blindness at presentation. However, over the follow-up period, black cases required significantly more glaucoma surgeries compared to black controls, whereas there was no significant difference in surgery between white cases and controls. There was no difference in medication changes in either case–control set. Keywords: health disparities, glaucoma surgery, glaucoma treatment, glaucoma medications 
format article
author Williams AM
Huang W
Muir KW
Stinnett SS
Stone JS
Rosdahl JA
author_facet Williams AM
Huang W
Muir KW
Stinnett SS
Stone JS
Rosdahl JA
author_sort Williams AM
title Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
title_short Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
title_full Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
title_fullStr Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
title_full_unstemmed Identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
title_sort identifying risk factors for blindness from primary open-angle glaucoma by race: a case–control study
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/600e53833f254ac99093a5020dcc3f93
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