Non-chemotoxic induction of cancer cell death using magnetic nanowires

Maria F Contreras,1 Rachid Sougrat,2 Amir Zaher,3 Timothy Ravasi,1,3 Jürgen Kosel3 1Division of Biological and Environmental Sciences and Engineering, 2Advanced Nanofabrication Imaging and Characterization, 3Division of Computer, Electrical and Mathematical Sciences and Engineering, King...

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Autores principales:	Contreras MF, Sougrat R, Zaher A, Ravasi T, Kosel J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/600f04aab9014330a67a84f223afb514
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spelling	oai:doaj.org-article:600f04aab9014330a67a84f223afb5142021-12-02T06:30:30ZNon-chemotoxic induction of cancer cell death using magnetic nanowires1178-2013https://doaj.org/article/600f04aab9014330a67a84f223afb5142015-03-01T00:00:00Zhttp://www.dovepress.com/non-chemotoxic-induction-of-cancer-cell-death-using-magnetic-nanowires-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Maria F Contreras,1 Rachid Sougrat,2 Amir Zaher,3 Timothy Ravasi,1,3 Jürgen Kosel3 1Division of Biological and Environmental Sciences and Engineering, 2Advanced Nanofabrication Imaging and Characterization, 3Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia Abstract: In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 µg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. Keywords: cell death induction, low frequency alternating magnetic field, nanomedicine, nanowire internalization, nickel nanowiresContreras MFSougrat RZaher ARavasi TKosel JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 2141-2153 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Contreras MF Sougrat R Zaher A Ravasi T Kosel J Non-chemotoxic induction of cancer cell death using magnetic nanowires
description	Maria F Contreras,1 Rachid Sougrat,2 Amir Zaher,3 Timothy Ravasi,1,3 Jürgen Kosel3 1Division of Biological and Environmental Sciences and Engineering, 2Advanced Nanofabrication Imaging and Characterization, 3Division of Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia Abstract: In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 µg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. Keywords: cell death induction, low frequency alternating magnetic field, nanomedicine, nanowire internalization, nickel nanowires
format	article
author	Contreras MF Sougrat R Zaher A Ravasi T Kosel J
author_facet	Contreras MF Sougrat R Zaher A Ravasi T Kosel J
author_sort	Contreras MF
title	Non-chemotoxic induction of cancer cell death using magnetic nanowires
title_short	Non-chemotoxic induction of cancer cell death using magnetic nanowires
title_full	Non-chemotoxic induction of cancer cell death using magnetic nanowires
title_fullStr	Non-chemotoxic induction of cancer cell death using magnetic nanowires
title_full_unstemmed	Non-chemotoxic induction of cancer cell death using magnetic nanowires
title_sort	non-chemotoxic induction of cancer cell death using magnetic nanowires
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/600f04aab9014330a67a84f223afb514
work_keys_str_mv	AT contrerasmf nonchemotoxicinductionofcancercelldeathusingmagneticnanowires AT sougratr nonchemotoxicinductionofcancercelldeathusingmagneticnanowires AT zahera nonchemotoxicinductionofcancercelldeathusingmagneticnanowires AT ravasit nonchemotoxicinductionofcancercelldeathusingmagneticnanowires AT koselj nonchemotoxicinductionofcancercelldeathusingmagneticnanowires
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Non-chemotoxic induction of cancer cell death using magnetic nanowires

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