The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs

Yuanyuan Wang,* Chao Pi,* Xianhu Feng, Yi Hou, Ling Zhao, Yumeng Wei Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China*These authors contributed equally to this workCorrespond...

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Autores principales:	Wang Y, Pi C, Feng X, Hou Y, Zhao L, Wei Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	oral bioavailability nanoparticle properties size shape surface properties Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6014007708ce4b94ab4f36f57d86aa10
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spelling	oai:doaj.org-article:6014007708ce4b94ab4f36f57d86aa102021-12-02T08:28:17ZThe Influence of Nanoparticle Properties on Oral Bioavailability of Drugs1178-2013https://doaj.org/article/6014007708ce4b94ab4f36f57d86aa102020-08-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-nanoparticle-properties-on-oral-bioavailability-of-dr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuanyuan Wang,* Chao Pi,* Xianhu Feng, Yi Hou, Ling Zhao, Yumeng Wei Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Zhao; Yumeng Wei Tel/ Fax +86 830 3162292; +86 830 3162291Email zhaoling-998@163.com; weiyumeng-268@163.comAbstract: Oral administration has been the most common therapeutic regimen in various diseases because of its high safety, convenience, lower costs, and high compliance of patients. However, susceptible in hostile gastrointestinal (GI) environment, many drugs show poor permeability across GI tract mucus and intestinal epithelium with poor oral absorption and limited therapeutic efficacy. In recent years, nanoparticulate drug delivery systems (NDDS) have become a hot research spot because of their unique advantages including protecting drug from premature degrading and interacting with the physiological environment, increasing intracellular penetration, and enhancing drug absorption. However, a slight change in physicochemistry of nanoparticles can significantly impact their interaction with biological pathways and alter the oral bioavailability of drugs. Hence, this review focuses on the factors affecting oral bioavailability from two aspects. On the one hand, the factors are the biochemical and physiological barriers in oral drugs delivery. On the other hand, the factors are the nanoparticle properties including size, surface properties, and shape of nanoparticles.Keywords: oral bioavailability, nanoparticle properties, size, shape, surface propertiesWang YPi CFeng XHou YZhao LWei YDove Medical Pressarticleoral bioavailabilitynanoparticle propertiessizeshapesurface propertiesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6295-6310 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral bioavailability nanoparticle properties size shape surface properties Medicine (General) R5-920
spellingShingle	oral bioavailability nanoparticle properties size shape surface properties Medicine (General) R5-920 Wang Y Pi C Feng X Hou Y Zhao L Wei Y The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
description	Yuanyuan Wang,* Chao Pi,* Xianhu Feng, Yi Hou, Ling Zhao, Yumeng Wei Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Zhao; Yumeng Wei Tel/ Fax +86 830 3162292; +86 830 3162291Email zhaoling-998@163.com; weiyumeng-268@163.comAbstract: Oral administration has been the most common therapeutic regimen in various diseases because of its high safety, convenience, lower costs, and high compliance of patients. However, susceptible in hostile gastrointestinal (GI) environment, many drugs show poor permeability across GI tract mucus and intestinal epithelium with poor oral absorption and limited therapeutic efficacy. In recent years, nanoparticulate drug delivery systems (NDDS) have become a hot research spot because of their unique advantages including protecting drug from premature degrading and interacting with the physiological environment, increasing intracellular penetration, and enhancing drug absorption. However, a slight change in physicochemistry of nanoparticles can significantly impact their interaction with biological pathways and alter the oral bioavailability of drugs. Hence, this review focuses on the factors affecting oral bioavailability from two aspects. On the one hand, the factors are the biochemical and physiological barriers in oral drugs delivery. On the other hand, the factors are the nanoparticle properties including size, surface properties, and shape of nanoparticles.Keywords: oral bioavailability, nanoparticle properties, size, shape, surface properties
format	article
author	Wang Y Pi C Feng X Hou Y Zhao L Wei Y
author_facet	Wang Y Pi C Feng X Hou Y Zhao L Wei Y
author_sort	Wang Y
title	The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
title_short	The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
title_full	The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
title_fullStr	The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
title_full_unstemmed	The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
title_sort	influence of nanoparticle properties on oral bioavailability of drugs
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6014007708ce4b94ab4f36f57d86aa10
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The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs

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