FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS

Abstract. The paper represents a synopsis of current publications concerning existence of free extracellular DNA. Such DNAs are not associated with cells of the organism, being revealed in nearly all body fluids. Recent data show that the cell-free DNA is determined in normal, healthy organism as we...

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Autor principal:	V. А. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	free extracellular dna methylation malignant cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/60148c454ab74b45b2d7e138eaa2f52b
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spelling	oai:doaj.org-article:60148c454ab74b45b2d7e138eaa2f52b2021-11-18T08:03:43ZFREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS1563-06252313-741X10.15789/1563-0625-2013-5-399-412https://doaj.org/article/60148c454ab74b45b2d7e138eaa2f52b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/657https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The paper represents a synopsis of current publications concerning existence of free extracellular DNA. Such DNAs are not associated with cells of the organism, being revealed in nearly all body fluids. Recent data show that the cell-free DNA is determined in normal, healthy organism as well. Increased level of free DNA plasma and serum are detectable in many diseases, including autoimmune disorders, malignant neoplasias, myocardial infarction, etc. In many cases, free DNA may be suggested as predictive markers for various distinct diseases, as well as worsening of their clinical course. Physiological role of free DNA is not yet clear, like as its importance in development of certain diseases. It was shown that free DNA may exert stimulatory or suppressive effects upon functions of immunocompetent cells. Free extracellular DNA may also perform an inducing role for autoimmune conditions. In addition, one may assume that free DNA may be a carrier of genetic information in the body between tumor and normal cells in the body, like as between normal cells in various organs and tissues.V. А. KozlovSPb RAACIarticlefree extracellular dnamethylationmalignant cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 399-412 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	free extracellular dna methylation malignant cells Immunologic diseases. Allergy RC581-607
spellingShingle	free extracellular dna methylation malignant cells Immunologic diseases. Allergy RC581-607 V. А. Kozlov FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
description	Abstract. The paper represents a synopsis of current publications concerning existence of free extracellular DNA. Such DNAs are not associated with cells of the organism, being revealed in nearly all body fluids. Recent data show that the cell-free DNA is determined in normal, healthy organism as well. Increased level of free DNA plasma and serum are detectable in many diseases, including autoimmune disorders, malignant neoplasias, myocardial infarction, etc. In many cases, free DNA may be suggested as predictive markers for various distinct diseases, as well as worsening of their clinical course. Physiological role of free DNA is not yet clear, like as its importance in development of certain diseases. It was shown that free DNA may exert stimulatory or suppressive effects upon functions of immunocompetent cells. Free extracellular DNA may also perform an inducing role for autoimmune conditions. In addition, one may assume that free DNA may be a carrier of genetic information in the body between tumor and normal cells in the body, like as between normal cells in various organs and tissues.
format	article
author	V. А. Kozlov
author_facet	V. А. Kozlov
author_sort	V. А. Kozlov
title	FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
title_short	FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
title_full	FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
title_fullStr	FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
title_full_unstemmed	FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS
title_sort	free extracellular dna in normal state and under pathological conditions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/60148c454ab74b45b2d7e138eaa2f52b
work_keys_str_mv	AT vakozlov freeextracellulardnainnormalstateandunderpathologicalconditions
_version_	1718422420221591552

FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS

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