The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is one of the main types of intestinal inflammatory diseases with intestine mucosal immune disorder. Intestine mucosal immune system plays a remarkable and important role in the etiology and pathoge...

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Autores principales:	Ning Liu, Gang Feng, Xiaoying Zhang, Qingjuan Hu, Shiqiang Sun, Jiaqi Sun, Yanan Sun, Ran Wang, Yan Zhang, Pengjie Wang, Yixuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cytokine intestinal epithelial cells immunocytes lactoferrin inflammatory bowel disease intestine mucosal immune system Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/60174677d7c64899900ad3260a7e1835
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spelling	oai:doaj.org-article:60174677d7c64899900ad3260a7e18352021-11-30T22:51:10ZThe Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease2296-861X10.3389/fnut.2021.759507https://doaj.org/article/60174677d7c64899900ad3260a7e18352021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.759507/fullhttps://doaj.org/toc/2296-861XInflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is one of the main types of intestinal inflammatory diseases with intestine mucosal immune disorder. Intestine mucosal immune system plays a remarkable and important role in the etiology and pathogenesis of IBD. Therefore, understanding the intestine mucosal immune mechanism is a key step to develop therapeutic interventions for IBD. Intestine mucosal immune system and IBD are influenced by various factors, such as inflammation, gut permeability, gut microbiota, and nutrients. Among these factors, emerging evidence show that nutrients play a key role in inflammation activation, integrity of intestinal barrier, and immune cell modulation. Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. Notably, LF has been reported to perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. The improved understanding of the properties of LF in intestine mucosal immune system and IBD will facilitate its application in nutrition, clinical medicine, and health. Herein, this review outlines the recent advancements on LF as a potential therapeutic intervention for IBD associated with intestine mucosal immune system dysfunction. We hope this review will provide a reference for future studies and lay a theoretical foundation for LF-based therapeutic interventions for IBD by understanding the particular effects of LF on intestine mucosal immune system.Ning LiuNing LiuGang FengGang FengXiaoying ZhangXiaoying ZhangQingjuan HuQingjuan HuShiqiang SunShiqiang SunJiaqi SunJiaqi SunYanan SunYanan SunRan WangRan WangYan ZhangYan ZhangYan ZhangPengjie WangPengjie WangYixuan LiYixuan LiFrontiers Media S.A.articlecytokineintestinal epithelial cellsimmunocyteslactoferrininflammatory bowel diseaseintestine mucosal immune systemNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokine intestinal epithelial cells immunocytes lactoferrin inflammatory bowel disease intestine mucosal immune system Nutrition. Foods and food supply TX341-641
spellingShingle	cytokine intestinal epithelial cells immunocytes lactoferrin inflammatory bowel disease intestine mucosal immune system Nutrition. Foods and food supply TX341-641 Ning Liu Ning Liu Gang Feng Gang Feng Xiaoying Zhang Xiaoying Zhang Qingjuan Hu Qingjuan Hu Shiqiang Sun Shiqiang Sun Jiaqi Sun Jiaqi Sun Yanan Sun Yanan Sun Ran Wang Ran Wang Yan Zhang Yan Zhang Yan Zhang Pengjie Wang Pengjie Wang Yixuan Li Yixuan Li The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
description	Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is one of the main types of intestinal inflammatory diseases with intestine mucosal immune disorder. Intestine mucosal immune system plays a remarkable and important role in the etiology and pathogenesis of IBD. Therefore, understanding the intestine mucosal immune mechanism is a key step to develop therapeutic interventions for IBD. Intestine mucosal immune system and IBD are influenced by various factors, such as inflammation, gut permeability, gut microbiota, and nutrients. Among these factors, emerging evidence show that nutrients play a key role in inflammation activation, integrity of intestinal barrier, and immune cell modulation. Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. Notably, LF has been reported to perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. The improved understanding of the properties of LF in intestine mucosal immune system and IBD will facilitate its application in nutrition, clinical medicine, and health. Herein, this review outlines the recent advancements on LF as a potential therapeutic intervention for IBD associated with intestine mucosal immune system dysfunction. We hope this review will provide a reference for future studies and lay a theoretical foundation for LF-based therapeutic interventions for IBD by understanding the particular effects of LF on intestine mucosal immune system.
format	article
author	Ning Liu Ning Liu Gang Feng Gang Feng Xiaoying Zhang Xiaoying Zhang Qingjuan Hu Qingjuan Hu Shiqiang Sun Shiqiang Sun Jiaqi Sun Jiaqi Sun Yanan Sun Yanan Sun Ran Wang Ran Wang Yan Zhang Yan Zhang Yan Zhang Pengjie Wang Pengjie Wang Yixuan Li Yixuan Li
author_facet	Ning Liu Ning Liu Gang Feng Gang Feng Xiaoying Zhang Xiaoying Zhang Qingjuan Hu Qingjuan Hu Shiqiang Sun Shiqiang Sun Jiaqi Sun Jiaqi Sun Yanan Sun Yanan Sun Ran Wang Ran Wang Yan Zhang Yan Zhang Yan Zhang Pengjie Wang Pengjie Wang Yixuan Li Yixuan Li
author_sort	Ning Liu
title	The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
title_short	The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
title_full	The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
title_fullStr	The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
title_full_unstemmed	The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
title_sort	functional role of lactoferrin in intestine mucosal immune system and inflammatory bowel disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/60174677d7c64899900ad3260a7e1835
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The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease

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