THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE

Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours. Objective...

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Main Authors:	Neila Raisa, Hidayat Sujuti, Masruroh Rahayu, Mochamad Dalhar
Format:	article
Language:	EN ID
Published:	University of Brawijaya 2019
Subjects:	gfap time of blood sampling acute stroke Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Online Access:	https://doaj.org/article/60178a4b1d0f4b689d0d70c41dc8961d
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spelling	oai:doaj.org-article:60178a4b1d0f4b689d0d70c41dc8961d2021-11-12T06:47:04ZTHE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE10.21776/ub.mnj.2019.005.01.52407-67242442-5001https://doaj.org/article/60178a4b1d0f4b689d0d70c41dc8961d2019-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/358https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours. Objective: To identify the difference in time of blood sampling with serum GFAP levels within 24 hours onset of ischemic stroke (IS) patients and intracerebral hemorrhage (ICH) strokes. Methods: Cross-sectional analysis with purposive sampling, sampling in IS and ICH strokes that arrive at the ER within 24-hour on-site. The serum GFAP examination was performed with ELISA. Results: In this study, 41 acute stroke patients with 24-hour onset of each stroke were grouped into group 1 (<6 hours), group 2 (6-12 hours) and group 3 (12-24 hours). One Way ANOVA and Tukey's analysis showed no significant difference in GFAP levels among the three groups in both IS and ICH. Conclusion: There was no significant difference in GFAP levels in samples <6 hours, 6-12 hours, and 12-24 hours in ischemic strokes and ICH strokes.Neila RaisaHidayat SujutiMasruroh RahayuMochamad DalharUniversity of Brawijayaarticlegfaptime of blood samplingacute strokeMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 5, Iss 1, Pp 30-33 (2019)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	gfap time of blood sampling acute stroke Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	gfap time of blood sampling acute stroke Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neila Raisa Hidayat Sujuti Masruroh Rahayu Mochamad Dalhar THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
description	Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke. Sampling within 6 hours after onset is the best time window, but in Indonesia, stroke patients often arrive late more than 6 hours. Objective: To identify the difference in time of blood sampling with serum GFAP levels within 24 hours onset of ischemic stroke (IS) patients and intracerebral hemorrhage (ICH) strokes. Methods: Cross-sectional analysis with purposive sampling, sampling in IS and ICH strokes that arrive at the ER within 24-hour on-site. The serum GFAP examination was performed with ELISA. Results: In this study, 41 acute stroke patients with 24-hour onset of each stroke were grouped into group 1 (<6 hours), group 2 (6-12 hours) and group 3 (12-24 hours). One Way ANOVA and Tukey's analysis showed no significant difference in GFAP levels among the three groups in both IS and ICH. Conclusion: There was no significant difference in GFAP levels in samples <6 hours, 6-12 hours, and 12-24 hours in ischemic strokes and ICH strokes.
format	article
author	Neila Raisa Hidayat Sujuti Masruroh Rahayu Mochamad Dalhar
author_facet	Neila Raisa Hidayat Sujuti Masruroh Rahayu Mochamad Dalhar
author_sort	Neila Raisa
title	THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
title_short	THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
title_full	THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
title_fullStr	THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
title_full_unstemmed	THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE
title_sort	influence of sampling time to serum glial fibrillary acidic protein (gfap) levels in acute stroke
publisher	University of Brawijaya
publishDate	2019
url	https://doaj.org/article/60178a4b1d0f4b689d0d70c41dc8961d
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THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE

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