Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a

Abstract An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether sc...

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Autores principales:	Annette Vriens, Eline B. Provost, Nelly D. Saenen, Patrick De Boever, Karen Vrijens, Oliver De Wever, Michelle Plusquin, Tim S. Nawrot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/601a48de609a4490ae954f11641d3bd9
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spelling	oai:doaj.org-article:601a48de609a4490ae954f11641d3bd92021-12-02T15:08:44ZChildren’s screen time alters the expression of saliva extracellular miR-222 and miR-146a10.1038/s41598-018-26351-22045-2322https://doaj.org/article/601a48de609a4490ae954f11641d3bd92018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26351-2https://doaj.org/toc/2045-2322Abstract An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether screen time, physical activity and BMI are associated with children’s salivary extracellular miR-222 and miR-146a expression. In 80 children the extracellular fraction of saliva was obtained by means of differential centrifugation and ultracentrifugation. Expression levels of miR-222 and miR-146a were profiled by qPCR. We studied the association between children’s salivary extracellular miRNA expression and screen time, physical activity and BMI using mixed models, while accounting for potential confounders. We found that higher screen time was positively associated with salivary extracellular miR-222 and miR-146a levels. On average, one hour more screen time use per week was associated with a 3.44% higher miR-222 (95% CI: 1.34 to 5.58; p = 0.002) and 1.84% higher miR-146a (95% CI: −0.04 to 3.75; p = 0.055) level in saliva. BMI and physical activity of the child were not significantly associated with either miR-222 or miR-146a. A sedentary behaviour, represented by screen time use in children, is associated with discernible changes in salivary expression of miR-146a and or miR-222. These miRNA targets may emerge attractive candidates to explore the role of these exposures in developmental processes of children’s health.Annette VriensEline B. ProvostNelly D. SaenenPatrick De BoeverKaren VrijensOliver De WeverMichelle PlusquinTim S. NawrotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annette Vriens Eline B. Provost Nelly D. Saenen Patrick De Boever Karen Vrijens Oliver De Wever Michelle Plusquin Tim S. Nawrot Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
description	Abstract An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether screen time, physical activity and BMI are associated with children’s salivary extracellular miR-222 and miR-146a expression. In 80 children the extracellular fraction of saliva was obtained by means of differential centrifugation and ultracentrifugation. Expression levels of miR-222 and miR-146a were profiled by qPCR. We studied the association between children’s salivary extracellular miRNA expression and screen time, physical activity and BMI using mixed models, while accounting for potential confounders. We found that higher screen time was positively associated with salivary extracellular miR-222 and miR-146a levels. On average, one hour more screen time use per week was associated with a 3.44% higher miR-222 (95% CI: 1.34 to 5.58; p = 0.002) and 1.84% higher miR-146a (95% CI: −0.04 to 3.75; p = 0.055) level in saliva. BMI and physical activity of the child were not significantly associated with either miR-222 or miR-146a. A sedentary behaviour, represented by screen time use in children, is associated with discernible changes in salivary expression of miR-146a and or miR-222. These miRNA targets may emerge attractive candidates to explore the role of these exposures in developmental processes of children’s health.
format	article
author	Annette Vriens Eline B. Provost Nelly D. Saenen Patrick De Boever Karen Vrijens Oliver De Wever Michelle Plusquin Tim S. Nawrot
author_facet	Annette Vriens Eline B. Provost Nelly D. Saenen Patrick De Boever Karen Vrijens Oliver De Wever Michelle Plusquin Tim S. Nawrot
author_sort	Annette Vriens
title	Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
title_short	Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
title_full	Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
title_fullStr	Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
title_full_unstemmed	Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
title_sort	children’s screen time alters the expression of saliva extracellular mir-222 and mir-146a
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/601a48de609a4490ae954f11641d3bd9
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Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a

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