A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae

A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae

In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.

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Autores principales: Matthieu J. Bergé, Chryslène Mercy, Isabelle Mortier-Barrière, Michael S. VanNieuwenhze, Yves V. Brun, Christophe Grangeasse, Patrice Polard, Nathalie Campo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/601e64aad69b4c8bb7b9c975910aeff2
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spelling oai:doaj.org-article:601e64aad69b4c8bb7b9c975910aeff22021-12-02T15:38:45ZA programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae10.1038/s41467-017-01716-92041-1723https://doaj.org/article/601e64aad69b4c8bb7b9c975910aeff22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01716-9https://doaj.org/toc/2041-1723In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.Matthieu J. BergéChryslène MercyIsabelle Mortier-BarrièreMichael S. VanNieuwenhzeYves V. BrunChristophe GrangeassePatrice PolardNathalie CampoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthieu J. Bergé
Chryslène Mercy
Isabelle Mortier-Barrière
Michael S. VanNieuwenhze
Yves V. Brun
Christophe Grangeasse
Patrice Polard
Nathalie Campo
A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
description In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.
format article
author Matthieu J. Bergé
Chryslène Mercy
Isabelle Mortier-Barrière
Michael S. VanNieuwenhze
Yves V. Brun
Christophe Grangeasse
Patrice Polard
Nathalie Campo
author_facet Matthieu J. Bergé
Chryslène Mercy
Isabelle Mortier-Barrière
Michael S. VanNieuwenhze
Yves V. Brun
Christophe Grangeasse
Patrice Polard
Nathalie Campo
author_sort Matthieu J. Bergé
title A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
title_short A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
title_full A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
title_fullStr A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
title_full_unstemmed A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae
title_sort programmed cell division delay preserves genome integrity during natural genetic transformation in streptococcus pneumoniae
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/601e64aad69b4c8bb7b9c975910aeff2
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