βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin network disruption which leads to polarity disruption and...

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Autores principales: Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
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spelling oai:doaj.org-article:601fb7f3dfa3458993f6399da1134e8f2021-12-02T15:22:55ZβA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells10.1038/s42003-021-02386-62399-3642https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02386-6https://doaj.org/toc/2399-3642Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin network disruption which leads to polarity disruption and degeneration through PITP β/PLC signaling.Peng ShangNadezda StepichevaKenneth TeelAustin McCauleyChristopher Scott FittingStacey HoseRhonda GrebeMeysam YazdankhahSayan GhoshHaitao LiuAnastasia StrizhakovaJoseph WeissImran A. BhuttoGerard A. LuttyAshwath JayagopalJiang QianJosé-Alain SahelJ. Samuel ZiglerJames T. HandaYuri SergeevRaju V. S. RajalaSimon WatkinsDebasish SinhaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Peng Shang
Nadezda Stepicheva
Kenneth Teel
Austin McCauley
Christopher Scott Fitting
Stacey Hose
Rhonda Grebe
Meysam Yazdankhah
Sayan Ghosh
Haitao Liu
Anastasia Strizhakova
Joseph Weiss
Imran A. Bhutto
Gerard A. Lutty
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
J. Samuel Zigler
James T. Handa
Yuri Sergeev
Raju V. S. Rajala
Simon Watkins
Debasish Sinha
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
description Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin network disruption which leads to polarity disruption and degeneration through PITP β/PLC signaling.
format article
author Peng Shang
Nadezda Stepicheva
Kenneth Teel
Austin McCauley
Christopher Scott Fitting
Stacey Hose
Rhonda Grebe
Meysam Yazdankhah
Sayan Ghosh
Haitao Liu
Anastasia Strizhakova
Joseph Weiss
Imran A. Bhutto
Gerard A. Lutty
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
J. Samuel Zigler
James T. Handa
Yuri Sergeev
Raju V. S. Rajala
Simon Watkins
Debasish Sinha
author_facet Peng Shang
Nadezda Stepicheva
Kenneth Teel
Austin McCauley
Christopher Scott Fitting
Stacey Hose
Rhonda Grebe
Meysam Yazdankhah
Sayan Ghosh
Haitao Liu
Anastasia Strizhakova
Joseph Weiss
Imran A. Bhutto
Gerard A. Lutty
Ashwath Jayagopal
Jiang Qian
José-Alain Sahel
J. Samuel Zigler
James T. Handa
Yuri Sergeev
Raju V. S. Rajala
Simon Watkins
Debasish Sinha
author_sort Peng Shang
title βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
title_short βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
title_full βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
title_fullStr βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
title_full_unstemmed βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
title_sort βa3/a1-crystallin regulates apical polarity and egfr endocytosis in retinal pigmented epithelial cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
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