Blood flow controls bone vascular function and osteogenesis

Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.

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Detalles Bibliográficos
Autores principales:	Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60215c37da3249169fe55bc0ec7526b8
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spelling	oai:doaj.org-article:60215c37da3249169fe55bc0ec7526b82021-12-02T17:31:50ZBlood flow controls bone vascular function and osteogenesis10.1038/ncomms136012041-1723https://doaj.org/article/60215c37da3249169fe55bc0ec7526b82016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13601https://doaj.org/toc/2041-1723Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.Saravana K. RamasamyAnjali P. KusumbeMaria SchillerDagmar ZeuschnerM. Gabriele BixelCarlo MiliaJaba GamrekelashviliAnne LimbourgAlexander MedvinskyMassimo M. SantoroFlorian P. LimbourgRalf H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saravana K. Ramasamy Anjali P. Kusumbe Maria Schiller Dagmar Zeuschner M. Gabriele Bixel Carlo Milia Jaba Gamrekelashvili Anne Limbourg Alexander Medvinsky Massimo M. Santoro Florian P. Limbourg Ralf H. Adams Blood flow controls bone vascular function and osteogenesis
description	Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.
format	article
author	Saravana K. Ramasamy Anjali P. Kusumbe Maria Schiller Dagmar Zeuschner M. Gabriele Bixel Carlo Milia Jaba Gamrekelashvili Anne Limbourg Alexander Medvinsky Massimo M. Santoro Florian P. Limbourg Ralf H. Adams
author_facet	Saravana K. Ramasamy Anjali P. Kusumbe Maria Schiller Dagmar Zeuschner M. Gabriele Bixel Carlo Milia Jaba Gamrekelashvili Anne Limbourg Alexander Medvinsky Massimo M. Santoro Florian P. Limbourg Ralf H. Adams
author_sort	Saravana K. Ramasamy
title	Blood flow controls bone vascular function and osteogenesis
title_short	Blood flow controls bone vascular function and osteogenesis
title_full	Blood flow controls bone vascular function and osteogenesis
title_fullStr	Blood flow controls bone vascular function and osteogenesis
title_full_unstemmed	Blood flow controls bone vascular function and osteogenesis
title_sort	blood flow controls bone vascular function and osteogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/60215c37da3249169fe55bc0ec7526b8
work_keys_str_mv	AT saravanakramasamy bloodflowcontrolsbonevascularfunctionandosteogenesis AT anjalipkusumbe bloodflowcontrolsbonevascularfunctionandosteogenesis AT mariaschiller bloodflowcontrolsbonevascularfunctionandosteogenesis AT dagmarzeuschner bloodflowcontrolsbonevascularfunctionandosteogenesis AT mgabrielebixel bloodflowcontrolsbonevascularfunctionandosteogenesis AT carlomilia bloodflowcontrolsbonevascularfunctionandosteogenesis AT jabagamrekelashvili bloodflowcontrolsbonevascularfunctionandosteogenesis AT annelimbourg bloodflowcontrolsbonevascularfunctionandosteogenesis AT alexandermedvinsky bloodflowcontrolsbonevascularfunctionandosteogenesis AT massimomsantoro bloodflowcontrolsbonevascularfunctionandosteogenesis AT florianplimbourg bloodflowcontrolsbonevascularfunctionandosteogenesis AT ralfhadams bloodflowcontrolsbonevascularfunctionandosteogenesis
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Blood flow controls bone vascular function and osteogenesis

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