STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA

Fifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1...

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Auteurs principaux:	N. I. Baranova, O. A. Levashova, S. V. Kozhenkova
Format:	article
Langue:	RU
Publié:	SPb RAACI 2015
Sujets:	chronic urticaria gene polymorphism cytokines Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/6021b285b7d947b4aea1db75f6535580
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spelling	oai:doaj.org-article:6021b285b7d947b4aea1db75f65355802021-11-18T08:03:44ZSTUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA1563-06252313-741X10.15789/1563-0625-2015-2-167-172https://doaj.org/article/6021b285b7d947b4aea1db75f65355802015-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/835https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1082A), IL-17A (G-197A) cytokine genes has been studied. No differences have been detected when studying IL-4 levels, depending on genetic variants of IL-4 gene in patients with CAU and CIU. Increased IL-10 amounts in patients with CIU still did not show any correlations with IL-10 genotype (G-1082A). Increased IL-17A levels in patients with CAU were associated with homozygous genotype of AA in comparison to control group, and with heterozygous GA genotype, in comparison to CIU group. The revealed differences of cytokines` genes polymorphism in CAU and CIU provide a molecular-genetic evidence for different clinical forms of chronic urticaria.N. I. BaranovaO. A. LevashovaS. V. KozhenkovaSPb RAACIarticlechronic urticariagene polymorphismcytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 2, Pp 167-172 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic urticaria gene polymorphism cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	chronic urticaria gene polymorphism cytokines Immunologic diseases. Allergy RC581-607 N. I. Baranova O. A. Levashova S. V. Kozhenkova STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
description	Fifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1082A), IL-17A (G-197A) cytokine genes has been studied. No differences have been detected when studying IL-4 levels, depending on genetic variants of IL-4 gene in patients with CAU and CIU. Increased IL-10 amounts in patients with CIU still did not show any correlations with IL-10 genotype (G-1082A). Increased IL-17A levels in patients with CAU were associated with homozygous genotype of AA in comparison to control group, and with heterozygous GA genotype, in comparison to CIU group. The revealed differences of cytokines` genes polymorphism in CAU and CIU provide a molecular-genetic evidence for different clinical forms of chronic urticaria.
format	article
author	N. I. Baranova O. A. Levashova S. V. Kozhenkova
author_facet	N. I. Baranova O. A. Levashova S. V. Kozhenkova
author_sort	N. I. Baranova
title	STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
title_short	STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
title_full	STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
title_fullStr	STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
title_full_unstemmed	STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
title_sort	studies on the role of cytokines polymorphism in pathogenesis of chronic urticaria
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/6021b285b7d947b4aea1db75f6535580
work_keys_str_mv	AT nibaranova studiesontheroleofcytokinespolymorphisminpathogenesisofchronicurticaria AT oalevashova studiesontheroleofcytokinespolymorphisminpathogenesisofchronicurticaria AT svkozhenkova studiesontheroleofcytokinespolymorphisminpathogenesisofchronicurticaria
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STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA

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