Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity

Lipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP...

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Autores principales:	Vinícius Costa Amador, Carlos André dos Santos-Silva, Lívia Maria Batista Vilela, Marx Oliveira-Lima, Mireli de Santana Rêgo, Ricardo Salas Roldan-Filho, Roberta Lane de Oliveira-Silva, Ayug Bezerra Lemos, Wilson Dias de Oliveira, José Ribamar Costa Ferreira-Neto, Sérgio Crovella, Ana Maria Benko-Iseppon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cationic peptides bioinformatics prediction directed analysis omics databases Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/602734e30f494106aa93a94ebea99495
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spelling	oai:doaj.org-article:602734e30f494106aa93a94ebea994952021-11-25T16:21:53ZLipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity10.3390/antibiotics101112812079-6382https://doaj.org/article/602734e30f494106aa93a94ebea994952021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1281https://doaj.org/toc/2079-6382Lipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.Vinícius Costa AmadorCarlos André dos Santos-SilvaLívia Maria Batista VilelaMarx Oliveira-LimaMireli de Santana RêgoRicardo Salas Roldan-FilhoRoberta Lane de Oliveira-SilvaAyug Bezerra LemosWilson Dias de OliveiraJosé Ribamar Costa Ferreira-NetoSérgio CrovellaAna Maria Benko-IsepponMDPI AGarticlecationic peptidesbioinformaticsprediction directed analysisomics databasesTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1281, p 1281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cationic peptides bioinformatics prediction directed analysis omics databases Therapeutics. Pharmacology RM1-950
spellingShingle	cationic peptides bioinformatics prediction directed analysis omics databases Therapeutics. Pharmacology RM1-950 Vinícius Costa Amador Carlos André dos Santos-Silva Lívia Maria Batista Vilela Marx Oliveira-Lima Mireli de Santana Rêgo Ricardo Salas Roldan-Filho Roberta Lane de Oliveira-Silva Ayug Bezerra Lemos Wilson Dias de Oliveira José Ribamar Costa Ferreira-Neto Sérgio Crovella Ana Maria Benko-Iseppon Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
description	Lipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.
format	article
author	Vinícius Costa Amador Carlos André dos Santos-Silva Lívia Maria Batista Vilela Marx Oliveira-Lima Mireli de Santana Rêgo Ricardo Salas Roldan-Filho Roberta Lane de Oliveira-Silva Ayug Bezerra Lemos Wilson Dias de Oliveira José Ribamar Costa Ferreira-Neto Sérgio Crovella Ana Maria Benko-Iseppon
author_facet	Vinícius Costa Amador Carlos André dos Santos-Silva Lívia Maria Batista Vilela Marx Oliveira-Lima Mireli de Santana Rêgo Ricardo Salas Roldan-Filho Roberta Lane de Oliveira-Silva Ayug Bezerra Lemos Wilson Dias de Oliveira José Ribamar Costa Ferreira-Neto Sérgio Crovella Ana Maria Benko-Iseppon
author_sort	Vinícius Costa Amador
title	Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
title_short	Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
title_full	Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
title_fullStr	Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
title_full_unstemmed	Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity
title_sort	lipid transfer proteins (ltps)—structure, diversity and roles beyond antimicrobial activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/602734e30f494106aa93a94ebea99495
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Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity

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