Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration

The activation of dendritic cells (DC) is associated with a metabolic switch from oxidative to glycolytic metabolism. Here, the authors show that both strong and weak stimuli cause an immediate increase in glycolysis, but only strong stimuli induce long-term glycolytic reprogramming.

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Autores principales:	Hannah Guak, Sara Al Habyan, Eric H. Ma, Haya Aldossary, Maia Al-Masri, So Yoon Won, Thomas Ying, Elizabeth D. Fixman, Russell G. Jones, Luke M. McCaffrey, Connie. M. Krawczyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/602bbe28597f4d06954fcdaaeb263744
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spelling	oai:doaj.org-article:602bbe28597f4d06954fcdaaeb2637442021-12-02T15:33:34ZGlycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration10.1038/s41467-018-04804-62041-1723https://doaj.org/article/602bbe28597f4d06954fcdaaeb2637442018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04804-6https://doaj.org/toc/2041-1723The activation of dendritic cells (DC) is associated with a metabolic switch from oxidative to glycolytic metabolism. Here, the authors show that both strong and weak stimuli cause an immediate increase in glycolysis, but only strong stimuli induce long-term glycolytic reprogramming.Hannah GuakSara Al HabyanEric H. MaHaya AldossaryMaia Al-MasriSo Yoon WonThomas YingElizabeth D. FixmanRussell G. JonesLuke M. McCaffreyConnie. M. KrawczykNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah Guak Sara Al Habyan Eric H. Ma Haya Aldossary Maia Al-Masri So Yoon Won Thomas Ying Elizabeth D. Fixman Russell G. Jones Luke M. McCaffrey Connie. M. Krawczyk Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
description	The activation of dendritic cells (DC) is associated with a metabolic switch from oxidative to glycolytic metabolism. Here, the authors show that both strong and weak stimuli cause an immediate increase in glycolysis, but only strong stimuli induce long-term glycolytic reprogramming.
format	article
author	Hannah Guak Sara Al Habyan Eric H. Ma Haya Aldossary Maia Al-Masri So Yoon Won Thomas Ying Elizabeth D. Fixman Russell G. Jones Luke M. McCaffrey Connie. M. Krawczyk
author_facet	Hannah Guak Sara Al Habyan Eric H. Ma Haya Aldossary Maia Al-Masri So Yoon Won Thomas Ying Elizabeth D. Fixman Russell G. Jones Luke M. McCaffrey Connie. M. Krawczyk
author_sort	Hannah Guak
title	Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
title_short	Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
title_full	Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
title_fullStr	Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
title_full_unstemmed	Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
title_sort	glycolytic metabolism is essential for ccr7 oligomerization and dendritic cell migration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/602bbe28597f4d06954fcdaaeb263744
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Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration

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