Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat
ABSTRACT The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latency. Unfortunately, Tat inhibitors are not clinicall...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
American Society for Microbiology
2019
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/602de632323a423fab4a3dba4bf5eaf7 |
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